Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142073..142578 Replicon chromosome
Accession NZ_CP100653
Organism Pseudomonas aeruginosa strain F13

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag NLS69_RS00655 Protein ID WP_003121619.1
Coordinates 142073..142354 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag NLS69_RS00660 Protein ID WP_003112628.1
Coordinates 142351..142578 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLS69_RS00630 (NLS69_00630) 137324..138673 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
NLS69_RS00635 (NLS69_00635) 138722..139408 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
NLS69_RS00640 (NLS69_00640) 139509..140243 + 735 WP_003117208.1 GntR family transcriptional regulator -
NLS69_RS00645 (NLS69_00645) 140423..140833 + 411 WP_003101225.1 aegerolysin family protein -
NLS69_RS00650 (NLS69_00650) 140865..141773 - 909 WP_016561475.1 LysR family transcriptional regulator -
NLS69_RS00655 (NLS69_00655) 142073..142354 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
NLS69_RS00660 (NLS69_00660) 142351..142578 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
NLS69_RS00665 (NLS69_00665) 142754..143374 - 621 WP_003101226.1 hypothetical protein -
NLS69_RS00670 (NLS69_00670) 143475..143975 + 501 WP_003112629.1 LEA type 2 family protein -
NLS69_RS00675 (NLS69_00675) 144048..144389 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
NLS69_RS00680 (NLS69_00680) 144471..145898 - 1428 WP_003083784.1 GABA permease -
NLS69_RS00685 (NLS69_00685) 146067..147560 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T250905 WP_003121619.1 NZ_CP100653:c142354-142073 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT250905 WP_003112628.1 NZ_CP100653:c142578-142351 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References