Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4928180..4928820 Replicon chromosome
Accession NZ_CP100652
Organism Pseudomonas putida strain HSM-C2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NL778_RS22440 Protein ID WP_012316423.1
Coordinates 4928410..4928820 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A427FTN1
Locus tag NL778_RS22435 Protein ID WP_012316422.1
Coordinates 4928180..4928410 (+) Length 77 a.a.

Genomic Context

NL778_RS22420NL778_RS22425NL778_RS22430NL778_RS22435NL778_RS22440NL778_RS22445NL778_RS22450NL778_RS22455NL778_RS22460NL778_RS22465NL778_RS22415
Location: 4925074..4926285 (1212 bp)
Type: Others
Protein ID: WP_042111775.1
Location: 4926278..4927372 (1095 bp)
Type: Others
Protein ID: WP_012316420.1
Location: 4927369..4928088 (720 bp)
Type: Others
Protein ID: WP_254466627.1
Location: 4928180..4928410 (231 bp)
Type: Antitoxin
Protein ID: WP_012316422.1
Location: 4928410..4928820 (411 bp)
Type: Toxin
Protein ID: WP_012316423.1
Location: 4928955..4929392 (438 bp)
Type: Others
Protein ID: WP_012316424.1
Location: 4929417..4930271 (855 bp)
Type: Others
Protein ID: WP_012316425.1
Location: 4930465..4930854 (390 bp)
Type: Others
Protein ID: WP_012316426.1
Location: 4930903..4931382 (480 bp)
Type: Others
Protein ID: WP_254466629.1
Location: 4931409..4931840 (432 bp)
Type: Others
Protein ID: WP_012316428.1
Location: 4923567..4924883 (1317 bp)
Type: Others
Protein ID: WP_254466626.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NL778_RS22415 (NL778_22415)4923567..4924883-1317WP_254466626.1precorrin-3B synthase-
NL778_RS22420 (NL778_22420)4925074..4926285+1212WP_042111775.1bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase-
NL778_RS22425 (NL778_22425)4926278..4927372+1095WP_012316420.1cobalt-precorrin-5B (C(1))-methyltransferase-
NL778_RS22430 (NL778_22430)4927369..4928088+720WP_254466627.1cobalt-precorrin-6A reductase-
NL778_RS22435 (NL778_22435)4928180..4928410+231WP_012316422.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
NL778_RS22440 (NL778_22440)4928410..4928820+411WP_012316423.1tRNA(fMet)-specific endonuclease VapCToxin
NL778_RS22445 (NL778_22445)4928955..4929392+438WP_012316424.1NfeD family protein-
NL778_RS22450 (NL778_22450)4929417..4930271+855WP_012316425.1SPFH domain-containing protein-
NL778_RS22455 (NL778_22455)4930465..4930854+390WP_012316426.1DUF2946 domain-containing protein-
NL778_RS22460 (NL778_22460)4930903..4931382+480WP_254466629.1copper chaperone PCu(A)C-
NL778_RS22465 (NL778_22465)4931409..4931840+432WP_012316428.1DUF2946 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15055.42 Da        Isoelectric Point: 8.0998

>T250903 WP_012316423.1 NZ_CP100652:4928410-4928820 [Pseudomonas putida]
MLKYMLDTNICIFTIKNKPQVVREAFNRHHGQLAISTVTLMELVYGAEKSAAPARNLSIVEGFVARLEVLDYDSHAAEHS
GQLRSELAKAGTPIGPFDQLIAGHARARGLTLVTNNLREFMRVPGLRVEDWLAMPG

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8487.35 Da        Isoelectric Point: 4.2821

>AT250903 WP_012316422.1 NZ_CP100652:4928180-4928410 [Pseudomonas putida]
MEQGAVFKSNRSQAIRLPKSVAFPEEVTRVDIVAVGRTRIITPAGESWDSWFDGEDASPDFMASRDQPADQEREGF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A427FTN1

References