Detailed information of TA system TA025090

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1150744..1151352
• Replicon: chromosome
• Accession: NC_015052
• Organism: Bifidobacterium longum subsp. infantis 157F

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3BGL7
• Locus tag: BLIF_RS04965
• Protein ID: WP_007056255.1
• Coordinates: 1150744..1151079 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3BGP0
• Locus tag: BLIF_RS04970
• Protein ID: WP_007056990.1
• Coordinates: 1151083..1151352 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLIF_RS04925	1145841..1146515	+	675	WP_077322431.1	YidC/Oxa1 family membrane protein insertase	-
BLIF_RS04930	1146617..1147237	+	621	WP_007054239.1	NUDIX hydrolase	-
BLIF_RS04935	1147266..1147589	+	324	WP_012471871.1	amidohydrolase	-
BLIF_RS11495	1148239..1148532	-	294	WP_012471870.1	hypothetical protein	-
BLIF_RS04945	1148625..1149266	-	642	WP_007056262.1	hypothetical protein	-
BLIF_RS04950	1149480..1149659	+	180	WP_007056286.1	antitoxin VbhA family protein	-
BLIF_RS04955	1149656..1150240	+	585	WP_007056278.1	Fic family protein	-
BLIF_RS04960	1150443..1150727	-	285	WP_007056282.1	hypothetical protein	-
BLIF_RS04965	1150744..1151079	-	336	WP_007056255.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BLIF_RS04970	1151083..1151352	-	270	WP_007056990.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BLIF_RS04975	1151537..1152706	-	1170	WP_007056274.1	ABC transporter permease	-
BLIF_RS04980	1152703..1153383	-	681	WP_003829413.1	ABC transporter ATP-binding protein	-
BLIF_RS04985	1153380..1154270	-	891	WP_007056280.1	hypothetical protein	-
BLIF_RS04990	1154267..1154782	-	516	WP_032685213.1	hypothetical protein	-
BLIF_RS04995	1154908..1155603	+	696	WP_003829410.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1131947..1165865	33918

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-87)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12650.60 Da
• Isoelectric Point: 9.1088

>T25090 WP_007056255.1 NC_015052:c1151079-1150744 [Bifidobacterium longum subsp. infantis 157F]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELFGQIAGLHPALNQPTAI

Nucleotide

• Length: 336 bp

>T25090 NC_015052:c1151079-1150744 [Bifidobacterium longum subsp. infantis 157F]
ATGCTCAAACCGGATTACACGGCGGCATTCCAGCGAGATATCAAGAAGCTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTACTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTTGGGCAAATAGCGGGTTTACATCCTGCTTTGAACCA
GCCGACGGCGATTTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9844.16 Da
• Isoelectric Point: 4.5742

>AT25090 WP_007056990.1 NC_015052:c1151352-1151083 [Bifidobacterium longum subsp. infantis 157F]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVREKRIPLNLSYTIVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI

Nucleotide

• Length: 270 bp

>AT25090 NC_015052:c1151352-1151083 [Bifidobacterium longum subsp. infantis 157F]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAAGCGCATTCCCCTAAACCTTTCCTATACGA
TCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCAACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Structures

Toxin

• AlphaFold DB: I3BGL7

Antitoxin

• AlphaFold DB: I3BGP0