Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 97864..98600 Replicon plasmid pwx17388plas
Accession NZ_CP100602
Organism Klebsiella pneumoniae strain WX17388

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag NLI98_RS25930 Protein ID WP_004098919.1
Coordinates 98118..98600 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7D3T1D0
Locus tag NLI98_RS25925 Protein ID WP_004213599.1
Coordinates 97864..98130 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLI98_RS25900 (NLI98_25890) 93096..93653 + 558 WP_004213590.1 recombinase family protein -
NLI98_RS25905 (NLI98_25895) 93656..96625 + 2970 WP_004213592.1 Tn3 family transposase -
NLI98_RS25910 (NLI98_25900) 96667..97161 + 495 WP_004213594.1 hypothetical protein -
NLI98_RS25915 (NLI98_25905) 97222..97425 + 204 WP_004213596.1 HHA domain-containing protein -
NLI98_RS25920 (NLI98_25910) 97439..97669 + 231 WP_004213598.1 hypothetical protein -
NLI98_RS25925 (NLI98_25915) 97864..98130 + 267 WP_004213599.1 DUF1778 domain-containing protein Antitoxin
NLI98_RS25930 (NLI98_25920) 98118..98600 + 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
NLI98_RS25935 (NLI98_25925) 99021..100248 + 1228 Protein_104 IS3 family transposase -
NLI98_RS25940 (NLI98_25930) 100244..100639 - 396 Protein_105 IS3 family transposase -
NLI98_RS25945 (NLI98_25935) 100814..101836 - 1023 WP_004214536.1 porphobilinogen synthase -
NLI98_RS25950 (NLI98_25940) 101900..103246 - 1347 WP_011154555.1 dihydroorotase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA2 1..222562 222562
- inside IScluster/Tn - - 93096..100248 7152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T250887 WP_004098919.1 NZ_CP100602:98118-98600 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10151.58 Da        Isoelectric Point: 4.5141

>AT250887 WP_004213599.1 NZ_CP100602:97864-98130 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRVLIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A7D3T1D0

References