Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3975321..3975940 Replicon chromosome
Accession NZ_CP100601
Organism Klebsiella pneumoniae strain WX17388

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NLI98_RS19265 Protein ID WP_002892050.1
Coordinates 3975722..3975940 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag NLI98_RS19260 Protein ID WP_002892066.1
Coordinates 3975321..3975695 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLI98_RS19250 (3970473) 3970473..3971666 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NLI98_RS19255 (3971689) 3971689..3974835 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
NLI98_RS19260 (3975321) 3975321..3975695 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
NLI98_RS19265 (3975722) 3975722..3975940 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NLI98_RS19270 (3976099) 3976099..3976665 + 567 WP_002892030.1 maltose O-acetyltransferase -
NLI98_RS19275 (3976637) 3976637..3976777 - 141 WP_004147370.1 hypothetical protein -
NLI98_RS19280 (3976798) 3976798..3977268 + 471 WP_002892026.1 YlaC family protein -
NLI98_RS19285 (3977243) 3977243..3978694 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
NLI98_RS19290 (3978795) 3978795..3979493 + 699 WP_002892021.1 GNAT family protein -
NLI98_RS19295 (3979490) 3979490..3979630 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
NLI98_RS19300 (3979630) 3979630..3979893 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T250882 WP_002892050.1 NZ_CP100601:3975722-3975940 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT250882 WP_002892066.1 NZ_CP100601:3975321-3975695 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References