25088

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 3562373..3563289 Replicon chromosome
Accession NC_014976
Organism Bacillus subtilis BSn5

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag BSN5_RS18775 Protein ID WP_015715744.1
Coordinates 3562543..3563289 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID -
Locus tag BSN5_RS18770 Protein ID WP_015715743.1
Coordinates 3562373..3562543 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSN5_RS18740 3559232..3559561 + 330 WP_003232660.1 phage-like element PBSX protein XkdW -
BSN5_RS18745 3559558..3559722 + 165 WP_015715740.1 XkdX family protein -
BSN5_RS18750 3559766..3560605 + 840 WP_015715741.1 phage-like element PBSX protein XepA -
BSN5_RS18755 3560658..3560927 + 270 WP_003232655.1 hemolysin XhlA family protein -
BSN5_RS18760 3560940..3561203 + 264 WP_014479566.1 phage holin -
BSN5_RS18765 3561216..3562109 + 894 WP_015715742.1 N-acetylmuramoyl-L-alanine amidase -
BSN5_RS22050 3562147..3562287 - 141 WP_144460135.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
BSN5_RS18770 3562373..3562543 - 171 WP_015715743.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
BSN5_RS18775 3562543..3563289 - 747 WP_015715744.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
BSN5_RS18780 3563399..3564400 - 1002 WP_014479569.1 inorganic phosphate transporter -
BSN5_RS18785 3564413..3565030 - 618 WP_003218470.1 DUF47 domain-containing protein -
BSN5_RS18790 3565306..3566622 - 1317 WP_015252262.1 serine/threonine exchanger -
BSN5_RS18795 3567011..3567961 + 951 WP_015715745.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29043.47 Da        Isoelectric Point: 4.6191

>T25088 WP_015715744.1 NC_014976:c3563289-3562543 [Bacillus subtilis BSn5]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHIYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T25088 NC_014976:c3563289-3562543 [Bacillus subtilis BSn5]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATATACCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCCTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6682.74 Da        Isoelectric Point: 11.1467

>AT25088 WP_015715743.1 NC_014976:c3562543-3562373 [Bacillus subtilis BSn5]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKRA

Download         Length: 171 bp

>AT25088 NC_014976:c3562543-3562373 [Bacillus subtilis BSn5]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTTAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAGAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References