Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 813126..813783 Replicon chromosome
Accession NZ_CP100601
Organism Klebsiella pneumoniae strain WX17388

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NLI98_RS04020 Protein ID WP_002916310.1
Coordinates 813373..813783 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NLI98_RS04015 Protein ID WP_002916312.1
Coordinates 813126..813392 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLI98_RS03990 (808321) 808321..809715 - 1395 WP_264452111.1 6-phospho-beta-glucosidase -
NLI98_RS03995 (809834) 809834..810562 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NLI98_RS04000 (810612) 810612..810923 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NLI98_RS04005 (811087) 811087..811746 + 660 WP_002916317.1 hemolysin III family protein -
NLI98_RS04010 (811897) 811897..812880 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
NLI98_RS04015 (813126) 813126..813392 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NLI98_RS04020 (813373) 813373..813783 + 411 WP_002916310.1 protein YgfX Toxin
NLI98_RS04025 (813790) 813790..814311 - 522 WP_004144730.1 flavodoxin FldB -
NLI98_RS04030 (814412) 814412..815308 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NLI98_RS04035 (815331) 815331..816044 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NLI98_RS04040 (816050) 816050..817783 + 1734 WP_088498560.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250875 WP_002916310.1 NZ_CP100601:813373-813783 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250875 WP_002916312.1 NZ_CP100601:813126-813392 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References