Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2736133..2736704 Replicon chromosome
Accession NZ_CP100596
Organism Enterococcus faecalis strain Chr-JH 2-2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NLG43_RS13380 Protein ID WP_002354774.1
Coordinates 2736133..2736474 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag NLG43_RS13385 Protein ID WP_002354773.1
Coordinates 2736474..2736704 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLG43_RS13375 (2732148) 2732148..2735762 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
NLG43_RS13380 (2736133) 2736133..2736474 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NLG43_RS13385 (2736474) 2736474..2736704 - 231 WP_002354773.1 hypothetical protein Antitoxin
NLG43_RS13390 (2737109) 2737109..2737324 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
NLG43_RS13395 (2737463) 2737463..2738455 + 993 WP_010817727.1 biotin--[acetyl-CoA-carboxylase] ligase -
NLG43_RS13400 (2738719) 2738719..2739357 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
NLG43_RS13405 (2740042) 2740042..2741658 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T250869 WP_002354774.1 NZ_CP100596:c2736474-2736133 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT250869 WP_002354773.1 NZ_CP100596:c2736704-2736474 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References