Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 490673..491320 Replicon chromosome
Accession NC_014974
Organism Thermus scotoductus SA-01

Toxin (Protein)


Gene name vapC Uniprot ID E8PLT6
Locus tag TSC_RS02650 Protein ID WP_015716453.1
Coordinates 490673..491059 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID E8PLT7
Locus tag TSC_RS02655 Protein ID WP_015716454.1
Coordinates 491060..491320 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TSC_RS02615 485705..486778 + 1074 WP_015716446.1 radical SAM protein -
TSC_RS02620 486815..487204 + 390 WP_019551701.1 NADH-quinone oxidoreductase subunit 15 -
TSC_RS02625 487201..487599 - 399 WP_015716448.1 PaaI family thioesterase -
TSC_RS02630 487630..488751 - 1122 WP_015716449.1 radical SAM family heme chaperone HemW -
TSC_RS02635 488752..489144 - 393 WP_015716450.1 HEPN domain-containing protein -
TSC_RS02640 489134..489451 - 318 WP_015716451.1 nucleotidyltransferase domain-containing protein -
TSC_RS02645 489456..490676 - 1221 WP_015716452.1 glycerate kinase -
TSC_RS02650 490673..491059 - 387 WP_015716453.1 type II toxin-antitoxin system VapC family toxin Toxin
TSC_RS02655 491060..491320 - 261 WP_015716454.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TSC_RS02660 491328..492614 - 1287 WP_015716455.1 glycolate oxidase subunit GlcF -
TSC_RS02665 492619..493665 - 1047 WP_015716456.1 FAD-binding protein -
TSC_RS02670 493658..495061 - 1404 WP_015716457.1 FAD-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-65)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14014.22 Da        Isoelectric Point: 5.6564

>T25086 WP_015716453.1 NC_014974:c491059-490673 [Thermus scotoductus SA-01]
MVLDTSAVLAILLREPGYETLLQRIVRGEPPKIGAPTLAEAGIVVVARLGFSYLHLLYELLEALGAEVIPFTEKHAREAI
RAYKEFGRAQHPAGLNFGDCLSYATARVEGMPLLYKGDDFAQTDLGQK

Download         Length: 387 bp

>T25086 NC_014974:c491059-490673 [Thermus scotoductus SA-01]
ATGGTCCTGGACACCTCAGCGGTCCTGGCGATCCTCCTTCGCGAGCCCGGTTACGAGACCTTGTTGCAGCGGATCGTCCG
CGGAGAGCCTCCAAAGATAGGGGCGCCTACCCTTGCGGAAGCTGGGATAGTGGTGGTAGCAAGGTTGGGGTTCAGCTATC
TCCATCTGCTTTACGAACTCCTGGAGGCGCTTGGAGCCGAGGTGATCCCCTTTACCGAGAAGCACGCTCGGGAAGCCATC
CGTGCCTATAAAGAGTTCGGCCGCGCCCAACACCCTGCGGGACTAAACTTCGGGGATTGCTTAAGCTATGCCACAGCCCG
TGTGGAGGGAATGCCTCTGCTCTATAAAGGCGACGACTTTGCCCAGACGGATTTAGGCCAAAAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9998.54 Da        Isoelectric Point: 6.3992

>AT25086 WP_015716454.1 NC_014974:c491320-491060 [Thermus scotoductus SA-01]
MAFTIRDKDVERLVEEVTRLTGESRAEAVRKALEMRLAELKPRQGLQNLLRTLEDKIWSKIPPEYLDKPLSQEETERLLG
YGPKGF

Download         Length: 261 bp

>AT25086 NC_014974:c491320-491060 [Thermus scotoductus SA-01]
ATGGCCTTCACCATACGCGATAAGGATGTGGAACGCCTGGTGGAGGAGGTGACCCGCCTCACCGGGGAGAGCAGGGCGGA
AGCGGTGCGGAAAGCCTTGGAGATGCGCCTTGCGGAGCTAAAACCCAGGCAAGGCCTTCAAAACCTTTTGCGCACCCTCG
AGGATAAAATCTGGTCCAAGATACCGCCGGAATACCTTGACAAGCCCCTTTCCCAAGAGGAAACGGAAAGGCTTCTGGGG
TATGGGCCCAAGGGGTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References