250857

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2353050..2353745 Replicon chromosome
Accession NZ_CP100596
Organism Enterococcus faecalis strain Chr-JH 2-2

Toxin (Protein)


Gene name IrrE Uniprot ID A0A059N529
Locus tag NLG43_RS11565 Protein ID WP_002373917.1
Coordinates 2353401..2353745 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag NLG43_RS11560 Protein ID WP_010829960.1
Coordinates 2353050..2353382 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLG43_RS11505 (2348655) 2348655..2349470 - 816 WP_164742164.1 PD-(D/E)XK nuclease-like domain-containing protein -
NLG43_RS11510 (2349433) 2349433..2350449 - 1017 WP_010821115.1 RecT family recombinase -
NLG43_RS11515 (2350500) 2350500..2350754 + 255 WP_002393052.1 hypothetical protein -
NLG43_RS11520 (2350729) 2350729..2350911 - 183 WP_258079925.1 hypothetical protein -
NLG43_RS11525 (2351051) 2351051..2351275 - 225 WP_002370012.1 hypothetical protein -
NLG43_RS11530 (2351272) 2351272..2351571 - 300 WP_002414895.1 hypothetical protein -
NLG43_RS11535 (2351638) 2351638..2351826 - 189 WP_127336215.1 hypothetical protein -
NLG43_RS11540 (2351823) 2351823..2352041 - 219 WP_010714171.1 aspartate decarboxylase -
NLG43_RS11545 (2352047) 2352047..2352247 - 201 WP_127336216.1 hypothetical protein -
NLG43_RS11550 (2352285) 2352285..2352554 - 270 WP_002365131.1 hypothetical protein -
NLG43_RS11555 (2352566) 2352566..2352757 - 192 WP_105194779.1 hypothetical protein -
NLG43_RS11560 (2353050) 2353050..2353382 + 333 WP_010829960.1 helix-turn-helix transcriptional regulator Antitoxin
NLG43_RS11565 (2353401) 2353401..2353745 + 345 WP_002373917.1 ImmA/IrrE family metallo-endopeptidase Toxin
NLG43_RS11570 (2353835) 2353835..2354599 + 765 WP_010711260.1 LysM domain-containing protein -
NLG43_RS11575 (2354693) 2354693..2355340 - 648 WP_252664458.1 hypothetical protein -
NLG43_RS11580 (2355526) 2355526..2356707 + 1182 WP_252664456.1 site-specific integrase -
NLG43_RS11585 (2356810) 2356810..2356959 - 150 WP_002356321.1 50S ribosomal protein L33 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2322078..2356707 34629


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13594.61 Da        Isoelectric Point: 5.6177

>T250857 WP_002373917.1 NZ_CP100596:2353401-2353745 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12711.27 Da        Isoelectric Point: 4.9833

>AT250857 WP_010829960.1 NZ_CP100596:2353050-2353382 [Enterococcus faecalis]
MSLFERIKSLAKTKNKNVKQVALELGFSENLFYKWKTNDPKAKDLEKVAEYFNVSVDYLLGRTDNTKATDEKNSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059N529

Antitoxin

Source ID Structure

References