Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 1169012..1169673 Replicon chromosome
Accession NZ_CP100553
Organism Pseudomonas hydrolytica strain KHPS2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NLY38_RS05385 Protein ID WP_129481803.1
Coordinates 1169012..1169431 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8I0VLZ4
Locus tag NLY38_RS05390 Protein ID WP_011921115.1
Coordinates 1169428..1169673 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY38_RS05340 (NLY38_05340) 1165005..1165211 - 207 WP_041772873.1 major capsid protein -
NLY38_RS05345 (NLY38_05345) 1165223..1165426 - 204 WP_012018527.1 hypothetical protein -
NLY38_RS05350 (NLY38_05350) 1165436..1165615 - 180 WP_012018528.1 hypothetical protein -
NLY38_RS05355 (NLY38_05355) 1165631..1166002 - 372 WP_254348336.1 hypothetical protein -
NLY38_RS05360 (NLY38_05360) 1166176..1166448 - 273 WP_254348337.1 hypothetical protein -
NLY38_RS05365 (NLY38_05365) 1166445..1167086 - 642 WP_254348339.1 DNA cytosine methyltransferase -
NLY38_RS05370 (NLY38_05370) 1167091..1167390 - 300 WP_254348341.1 DUF5447 family protein -
NLY38_RS05375 (NLY38_05375) 1167720..1168001 - 282 WP_254348343.1 DNA-binding protein -
NLY38_RS05380 (NLY38_05380) 1168463..1168756 + 294 WP_254348345.1 hypothetical protein -
NLY38_RS05385 (NLY38_05385) 1169012..1169431 - 420 WP_129481803.1 type II toxin-antitoxin system VapC family toxin Toxin
NLY38_RS05390 (NLY38_05390) 1169428..1169673 - 246 WP_011921115.1 Arc family DNA-binding protein Antitoxin
NLY38_RS05395 (NLY38_05395) 1169726..1169977 - 252 Protein_1064 tyrosine-type recombinase/integrase -
NLY38_RS05400 (NLY38_05400) 1170399..1171292 + 894 WP_254348347.1 hypothetical protein -
NLY38_RS05405 (NLY38_05405) 1171413..1172519 + 1107 WP_254348349.1 hypothetical protein -
NLY38_RS05410 (NLY38_05410) 1172757..1173422 - 666 WP_195882877.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1150722..1179103 28381


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(13-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15067.30 Da        Isoelectric Point: 4.2947

>T250852 WP_129481803.1 NZ_CP100553:c1169431-1169012 [Pseudomonas hydrolytica]
MILLDTNVLSELMRAKPAPQVLEWVDAQPVGDLVITSITVAEILYGIARMPDGKRKQGLLDVASVMFDEDFAGNILPFDA
DAAVHYAEIAAETEAKGRVVDMADAQIAAIGRLHDAVIATRNIRHFETLGVALVDPWSN

Download         Length: 420 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8990.24 Da        Isoelectric Point: 10.7217

>AT250852 WP_011921115.1 NZ_CP100553:c1169673-1169428 [Pseudomonas hydrolytica]
MAAITIRNLDDDLKAQLRIVAASHGRSMEEEVRFIIRQALSRQEKRGGLGSRIHSRFAAVGGADLELPERKTKARAASFD
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References