Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1241562..1243153 Replicon chromosome
Accession NZ_CP100551
Organism Pseudomonas sp. KHPS1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NLY39_RS05660 Protein ID WP_254299627.1
Coordinates 1241562..1242887 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID W6RJ44
Locus tag NLY39_RS05665 Protein ID WP_003459718.1
Coordinates 1242887..1243153 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLY39_RS05645 (NLY39_05645) 1238540..1238890 - 351 Protein_1115 TraI domain-containing protein -
NLY39_RS05650 (NLY39_05650) 1239018..1239683 + 666 WP_198402222.1 LysR substrate-binding domain-containing protein -
NLY39_RS05655 (NLY39_05655) 1239746..1241002 - 1257 WP_096827184.1 integrase domain-containing protein -
NLY39_RS05660 (NLY39_05660) 1241562..1242887 + 1326 WP_254299627.1 HipA domain-containing protein Toxin
NLY39_RS05665 (NLY39_05665) 1242887..1243153 + 267 WP_003459718.1 helix-turn-helix transcriptional regulator Antitoxin
NLY39_RS05670 (NLY39_05670) 1243202..1243987 + 786 WP_254299629.1 inositol monophosphatase family protein -
NLY39_RS05675 (NLY39_05675) 1244094..1244207 + 114 Protein_1121 transposase -
NLY39_RS05680 (NLY39_05680) 1244399..1244743 + 345 WP_124187315.1 IS66 family insertion sequence element accessory protein TnpB -
NLY39_RS05685 (NLY39_05685) 1244779..1246287 + 1509 WP_073625071.1 IS66 family transposase -
NLY39_RS05690 (NLY39_05690) 1246291..1246869 + 579 WP_003291613.1 plasmid pRiA4b ORF-3 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1207155..1382727 175572


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49190.67 Da        Isoelectric Point: 4.9601

>T250850 WP_254299627.1 NZ_CP100551:1241562-1242887 [Pseudomonas sp. KHPS1]
MHNLTLQVYRDGQWRNAMELRFEQPEEGLEGACAYGYQQGYLVDSLESVGTRLNAAVSAAYPLGWDSWRDKKAPAFLFDI
LPSGAARRFLLKRLGGERPEGLNLDLYLLGRCTPAPIGNLRIKESVEAIAGSPVLGFTRDEVISRDSRFLEYAYEQGAAI
GGATGAGGEAPKLLLTEDRHGALHPDAVLPDADAVQHWFVKFARNKASQTDQDILRSEYCFYRAVQQLGMDTVAAEGLAL
EEGNKPSLWMHRFDREISSTGVCRTAVESMYSLCGVTEAGSYMLHTQVLGKLVELWRAVGQEQQVGDLVFEYMRRDLLNQ
ILGNSDNHGRNTAILRSEQGVRLAPIYDLAPMVMDEEGVTRTTKWPKHIELAGDVNWRAACDEVAEWIDADELFQRLRLA
AQDFLALPDLLSAEGLPDSTMSHPHIALRNLRQRLNQWGLV

Download         Length: 1326 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9933.55 Da        Isoelectric Point: 10.9502

>AT250850 WP_003459718.1 NZ_CP100551:1242887-1243153 [Pseudomonas sp. KHPS1]
MDILERNRILNELQQQLASGEITIGGAVRRLRKEVTGLQQARFAQMCKLSLRALRQLELDESNPTVQTLNSVFNPFGMQV
GIVPKTPR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W6RJ44

References