Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 54178..54779 Replicon plasmid pLH09-a-D
Accession NZ_CP100548
Organism Escherichia coli strain LH09-a

Toxin (Protein)


Gene name doc Uniprot ID F4TND7
Locus tag NLZ06_RS24630 Protein ID WP_001216030.1
Coordinates 54399..54779 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag NLZ06_RS24625 Protein ID WP_001190712.1
Coordinates 54178..54399 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ06_RS24615 (NLZ06_24615) 51174..52442 - 1269 WP_029401415.1 restriction endonuclease subunit S -
NLZ06_RS24620 (NLZ06_24620) 52439..53995 - 1557 WP_029401414.1 type I restriction-modification system subunit M -
NLZ06_RS24625 (NLZ06_24625) 54178..54399 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NLZ06_RS24630 (NLZ06_24630) 54399..54779 + 381 WP_001216030.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NLZ06_RS24635 (NLZ06_24635) 54784..54963 + 180 WP_000113018.1 hypothetical protein -
NLZ06_RS24640 (NLZ06_24640) 54991..56034 + 1044 WP_000648833.1 DUF968 domain-containing protein -
NLZ06_RS24645 (NLZ06_24645) 56123..56575 + 453 WP_032305380.1 hypothetical protein -
NLZ06_RS24650 (NLZ06_24650) 56662..57855 + 1194 WP_000219604.1 terminase -
NLZ06_RS24655 (NLZ06_24655) 57855..59339 + 1485 WP_000124150.1 terminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92693 92693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13601.29 Da        Isoelectric Point: 5.1408

>T250849 WP_001216030.1 NZ_CP100548:54399-54779 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEDITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT250849 WP_001190712.1 NZ_CP100548:54178-54399 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1W8Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References