25084

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 336522..337081 Replicon chromosome
Accession NC_014966
Organism Vibrio vulnificus MO6-24/O

Toxin (Protein)


Gene name relE Uniprot ID A0A3Q0L0M9
Locus tag VVMO6_RS16300 Protein ID WP_011082349.1
Coordinates 336803..337081 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3Q0L0M2
Locus tag VVMO6_RS16295 Protein ID WP_011082348.1
Coordinates 336522..336806 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VVMO6_RS16270 332049..333242 + 1194 WP_011082341.1 glycine C-acetyltransferase -
VVMO6_RS16275 333293..334318 + 1026 WP_197672410.1 L-threonine 3-dehydrogenase -
VVMO6_RS16280 334398..334898 - 501 WP_015727533.1 hypothetical protein -
VVMO6_RS16285 334976..335239 - 264 WP_015727534.1 hypothetical protein -
VVMO6_RS16290 335479..336213 - 735 WP_102969971.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
VVMO6_RS16295 336522..336806 + 285 WP_011082348.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VVMO6_RS16300 336803..337081 + 279 WP_011082349.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VVMO6_RS23410 337110..337241 - 132 WP_015727536.1 DUF3265 domain-containing protein -
VVMO6_RS24055 337231..337512 - 282 WP_127463377.1 hypothetical protein -
VVMO6_RS16305 337517..337774 - 258 WP_015727538.1 hypothetical protein -
VVMO6_RS16310 337784..338284 - 501 WP_038939959.1 hypothetical protein -
VVMO6_RS16315 338568..339002 - 435 WP_038939960.1 hypothetical protein -
VVMO6_RS16320 338981..339415 - 435 WP_038939961.1 hypothetical protein -
VVMO6_RS16325 340214..340801 - 588 WP_015727540.1 DUF1471 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-45)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10932.66 Da        Isoelectric Point: 4.2397

>T25084 WP_011082349.1 NC_014966:336803-337081 [Vibrio vulnificus MO6-24/O]
MILWEEESLNDREKIFEFLYDFNPDVPEKTDNLIEAKVENLLEQPLMGVQRDSILGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T25084 NC_014966:336803-337081 [Vibrio vulnificus MO6-24/O]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGTGCC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATAGCA
TCCTCGGTCGATTACTCATTATTCCTGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTCCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11083.43 Da        Isoelectric Point: 9.2167

>AT25084 WP_011082348.1 NC_014966:336522-336806 [Vibrio vulnificus MO6-24/O]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT25084 NC_014966:336522-336806 [Vibrio vulnificus MO6-24/O]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCATTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L0M9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q0L0M2

References