Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4198002..4198499 Replicon chromosome
Accession NZ_CP100544
Organism Escherichia coli strain LH09-a

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NLZ06_RS20145 Protein ID WP_001173343.1
Coordinates 4198002..4198175 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NLZ06_RS20150 Protein ID WP_000398619.1
Coordinates 4198203..4198499 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ06_RS20135 (4194672) 4194672..4196129 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
NLZ06_RS20140 (4196366) 4196366..4197883 + 1518 WP_001295074.1 lysine--tRNA ligase -
NLZ06_RS20145 (4198002) 4198002..4198175 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NLZ06_RS20150 (4198203) 4198203..4198499 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NLZ06_RS20155 (4198726) 4198726..4198998 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NLZ06_RS20160 (4199010) 4199010..4199240 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
NLZ06_RS20165 (4199421) 4199421..4201052 + 1632 WP_001216486.1 sensor histidine kinase -
NLZ06_RS20170 (4201049) 4201049..4201768 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T250838 WP_001173343.1 NZ_CP100544:c4198175-4198002 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT250838 WP_000398619.1 NZ_CP100544:c4198499-4198203 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References