Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3424164..3424782 Replicon chromosome
Accession NZ_CP100544
Organism Escherichia coli strain LH09-a

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NLZ06_RS16510 Protein ID WP_001291435.1
Coordinates 3424564..3424782 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NLZ06_RS16505 Protein ID WP_000344800.1
Coordinates 3424164..3424538 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ06_RS16495 (3419253) 3419253..3420446 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NLZ06_RS16500 (3420469) 3420469..3423618 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NLZ06_RS16505 (3424164) 3424164..3424538 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NLZ06_RS16510 (3424564) 3424564..3424782 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NLZ06_RS16515 (3424954) 3424954..3425505 + 552 WP_254521253.1 maltose O-acetyltransferase -
NLZ06_RS16520 (3425621) 3425621..3426091 + 471 WP_000136192.1 YlaC family protein -
NLZ06_RS16525 (3426255) 3426255..3427805 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NLZ06_RS16530 (3427847) 3427847..3428200 - 354 WP_000878141.1 DUF1428 family protein -
NLZ06_RS16540 (3428579) 3428579..3428890 + 312 WP_000409911.1 MGMT family protein -
NLZ06_RS16545 (3428921) 3428921..3429493 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T250834 WP_001291435.1 NZ_CP100544:3424564-3424782 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT250834 WP_000344800.1 NZ_CP100544:3424164-3424538 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References