25083

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2578385..2580213 Replicon chromosome
Accession NC_014965
Organism Vibrio vulnificus MO6-24/O

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag VVMO6_RS12030 Protein ID WP_013572329.1
Coordinates 2578385..2579746 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag VVMO6_RS12035 Protein ID WP_029786578.1
Coordinates 2579731..2580213 (+) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VVMO6_RS12005 2573817..2575481 + 1665 WP_013572327.1 DNA repair protein RecN -
VVMO6_RS12010 2575660..2576019 + 360 WP_011078463.1 outer membrane protein assembly factor BamE -
VVMO6_RS12015 2576115..2576468 - 354 WP_011078464.1 RnfH family protein -
VVMO6_RS12020 2576465..2576896 - 432 WP_026050324.1 ubiquinone-binding protein -
VVMO6_RS12025 2577012..2577497 + 486 WP_011078466.1 SsrA-binding protein SmpB -
VVMO6_RS12030 2578385..2579746 + 1362 WP_013572329.1 type II toxin-antitoxin system HipA family toxin Toxin
VVMO6_RS12035 2579731..2580213 + 483 WP_029786578.1 helix-turn-helix domain-containing protein Antitoxin
VVMO6_RS12040 2580652..2582394 - 1743 WP_013572330.1 lysophospholipid acyltransferase family protein -
VVMO6_RS12045 2582437..2582874 - 438 WP_011078502.1 YHS domain-containing protein -
VVMO6_RS12050 2582889..2583644 - 756 WP_013572331.1 NRDE family protein -
VVMO6_RS12055 2583646..2584200 - 555 WP_013572332.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51441.20 Da        Isoelectric Point: 4.8182

>T25083 WP_013572329.1 NC_014965:2578385-2579746 [Vibrio vulnificus MO6-24/O]
MEELTVQAFIRSEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFIGIADTLSDLV
PKEVLLQELEVTASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T25083 NC_014965:2578385-2579746 [Vibrio vulnificus MO6-24/O]
ATGGAAGAACTAACCGTACAAGCTTTTATCAGAAGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATCACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCTTTTTTGATGACATGGGTAAACCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGTGGCGCTAGTAGACGATACTGGGTCAAACACCTAGATATTGAAGACCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACAATGTCGCCTATCGGTAACTTAAGAATAAAAGACTCTCTTCCTGAGCGCTACGAAGTAGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACAGCAAAGAGGGGCAGCCGCA
GGTGGTGCAACAGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTGGTTTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGACCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTGTGGCTTCCTCGATTTGATGTTCAAATTATTGAGCA
ACAAATAGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGCAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTCATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAACACTTCATTCTT
AAAAGGTGATGGAGTCATAAAGCTTGCTCCCGTTTACGACTTCGCACCAATGAAAGCTGATCCTGAAGGCATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTTGGCGGAACTTACGACTTCATCGGAATAGCGGACACCTTATCTGATCTCGTG
CCAAAAGAAGTGTTATTACAAGAGCTAGAGGTTACTGCAAGTAAATGCATTGATTTAAAGCAGAGACTAGCATTACGAGG
AGTACCAGAACAAATCTTAGAGATGCCAGCCGTTGGACTTAATCATATATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17535.05 Da        Isoelectric Point: 10.8446

>AT25083 WP_029786578.1 NC_014965:2579731-2580213 [Vibrio vulnificus MO6-24/O]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT25083 NC_014965:2579731-2580213 [Vibrio vulnificus MO6-24/O]
ATGGGGGCTACTATGAATAAGCCAAGCAATAAAGAGTCCGTACAAGATACCGTTGCTCGTCTAAGAGCAAACCGAAATCA
ACATCAGCCCAAGACTGGGACGGATGCAACTCATTCGACCAAAGAACGATCGCAACTTAATACTCCGACTAGATCGAAAA
CCTCAAAAAACGCCAAAGCAGTAAGTGCAGCAGAACGCAAAACAGAGGCAAACAAAATCATCAAACACTTATTGCTTGGA
GAGCTAACACAAGGCCAAGCGTTAAAAAGTTTACGCATTAATATACTGGGACTCAAACAGGATGTGTTCGCAAGACTTGT
AGATGTCTCAAGAAAAACACTCTCAGATATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCA
AGCCATTTGGCTTAAAAGTCGGAATGCTACCGTCTTCTCCCGATGTGTTAAAATCGCTACTAATAGATGGTGAGGCTGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References