Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1283896..1284521 Replicon chromosome
Accession NZ_CP100544
Organism Escherichia coli strain LH09-a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NLZ06_RS06210 Protein ID WP_000911330.1
Coordinates 1284123..1284521 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NLZ06_RS06205 Protein ID WP_000450524.1
Coordinates 1283896..1284123 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ06_RS06180 (1279699) 1279699..1280169 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NLZ06_RS06185 (1280169) 1280169..1280741 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NLZ06_RS06190 (1280887) 1280887..1281765 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NLZ06_RS06195 (1281782) 1281782..1282816 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NLZ06_RS06200 (1283029) 1283029..1283742 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NLZ06_RS06205 (1283896) 1283896..1284123 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NLZ06_RS06210 (1284123) 1284123..1284521 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NLZ06_RS06215 (1284668) 1284668..1285531 + 864 WP_001267508.1 neutral zinc metallopeptidase -
NLZ06_RS06220 (1285546) 1285546..1287561 + 2016 WP_000829355.1 tRNA cytosine(34) acetyltransferase TmcA -
NLZ06_RS06225 (1287635) 1287635..1288333 + 699 WP_000679823.1 esterase -
NLZ06_RS06230 (1288443) 1288443..1288643 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T250827 WP_000911330.1 NZ_CP100544:1284123-1284521 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT250827 WP_000450524.1 NZ_CP100544:1283896-1284123 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References