Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 264226..264812 Replicon chromosome
Accession NZ_CP100544
Organism Escherichia coli strain LH09-a

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag NLZ06_RS01205 Protein ID WP_042014162.1
Coordinates 264226..264456 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NLZ06_RS01210 Protein ID WP_000593555.1
Coordinates 264453..264812 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ06_RS01195 (260263) 260263..262998 + 2736 WP_000149168.1 ribosome-associated ATPase/putative transporter RbbA -
NLZ06_RS01200 (262998) 262998..264122 + 1125 WP_254521280.1 ABC transporter permease -
NLZ06_RS01205 (264226) 264226..264456 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
NLZ06_RS01210 (264453) 264453..264812 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NLZ06_RS01215 (264932) 264932..265333 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NLZ06_RS01220 (265339) 265339..266145 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NLZ06_RS01225 (266142) 266142..266906 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NLZ06_RS01230 (266906) 266906..267739 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NLZ06_RS01235 (267736) 267736..268680 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T250822 WP_042014162.1 NZ_CP100544:264226-264456 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT250822 WP_000593555.1 NZ_CP100544:264453-264812 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References