25082

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1548845..1549383 Replicon chromosome
Accession NC_014965
Organism Vibrio vulnificus MO6-24/O

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag VVMO6_RS07260 Protein ID WP_001247271.1
Coordinates 1548845..1549144 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag VVMO6_RS07265 Protein ID WP_011080384.1
Coordinates 1549141..1549383 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VVMO6_RS07220 1544094..1544522 + 429 WP_013571720.1 GNAT family N-acetyltransferase -
VVMO6_RS07225 1544609..1545088 + 480 WP_013571721.1 GNAT family N-acetyltransferase -
VVMO6_RS23180 1545070..1545213 + 144 WP_072612500.1 DUF3265 domain-containing protein -
VVMO6_RS23185 1545547..1545669 + 123 WP_072612501.1 DUF3265 domain-containing protein -
VVMO6_RS07230 1545762..1546028 + 267 WP_013571723.1 hypothetical protein -
VVMO6_RS07235 1546190..1546501 + 312 WP_044023869.1 antibiotic biosynthesis monooxygenase -
VVMO6_RS23720 1546492..1546650 + 159 WP_072612491.1 DUF3265 domain-containing protein -
VVMO6_RS07240 1546643..1546972 + 330 WP_013571675.1 hypothetical protein -
VVMO6_RS07245 1547129..1547635 + 507 WP_013571676.1 GNAT family N-acetyltransferase -
VVMO6_RS23190 1547645..1547809 + 165 WP_102970004.1 DUF3265 domain-containing protein -
VVMO6_RS07250 1547737..1548099 + 363 WP_013571725.1 DUF4144 domain-containing protein -
VVMO6_RS23195 1548143..1548232 + 90 Protein_1463 DUF3265 domain-containing protein -
VVMO6_RS24160 1548258..1548731 + 474 WP_044023871.1 hypothetical protein -
VVMO6_RS23200 1548679..1548837 + 159 WP_072612492.1 DUF3265 domain-containing protein -
VVMO6_RS07260 1548845..1549144 - 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VVMO6_RS07265 1549141..1549383 - 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
VVMO6_RS23205 1549417..1549569 + 153 WP_072612493.1 DUF3265 domain-containing protein -
VVMO6_RS07270 1549589..1549891 + 303 WP_013571727.1 hypothetical protein -
VVMO6_RS23210 1549929..1549997 + 69 WP_080252462.1 DUF3265 domain-containing protein -
VVMO6_RS07275 1550136..1550357 + 222 WP_000076907.1 VF530 family protein -
VVMO6_RS23215 1550368..1550496 + 129 WP_080557521.1 DUF3265 domain-containing protein -
VVMO6_RS23220 1550839..1550982 + 144 WP_072612495.1 DUF3265 domain-containing protein -
VVMO6_RS07280 1550979..1551281 + 303 WP_011080371.1 hypothetical protein -
VVMO6_RS07285 1551805..1552362 + 558 Protein_1475 hypothetical protein -
VVMO6_RS07290 1552504..1552965 + 462 WP_013571730.1 GNAT family N-acetyltransferase -
VVMO6_RS23725 1552962..1553072 + 111 Protein_1477 DUF3265 domain-containing protein -
VVMO6_RS07295 1553099..1553371 + 273 WP_013571731.1 hypothetical protein -
VVMO6_RS07300 1553534..1553998 + 465 WP_013571732.1 ASCH domain-containing protein -
VVMO6_RS23230 1554003..1554125 + 123 Protein_1480 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flp1 / VP1611 1185032..1724682 539650
- inside Integron - - 1434218..1558944 124726


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T25082 WP_001247271.1 NC_014965:c1549144-1548845 [Vibrio vulnificus MO6-24/O]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T25082 NC_014965:c1549144-1548845 [Vibrio vulnificus MO6-24/O]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAACCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATAGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT25082 WP_011080384.1 NC_014965:c1549383-1549141 [Vibrio vulnificus MO6-24/O]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT25082 NC_014965:c1549383-1549141 [Vibrio vulnificus MO6-24/O]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References