Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4635758..4636274 Replicon chromosome
Accession NZ_CP100542
Organism Klebsiella pneumoniae strain LH09-d

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NLZ07_RS22705 Protein ID WP_002886902.1
Coordinates 4635758..4636042 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NLZ07_RS22710 Protein ID WP_002886901.1
Coordinates 4636032..4636274 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ07_RS22680 (4631174) 4631174..4631437 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NLZ07_RS22685 (4631567) 4631567..4631740 + 174 WP_032410138.1 hypothetical protein -
NLZ07_RS22690 (4631743) 4631743..4632486 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
NLZ07_RS22695 (4632843) 4632843..4634981 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NLZ07_RS22700 (4635290) 4635290..4635754 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NLZ07_RS22705 (4635758) 4635758..4636042 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ07_RS22710 (4636032) 4636032..4636274 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NLZ07_RS22715 (4636352) 4636352..4638262 - 1911 WP_009486549.1 PRD domain-containing protein -
NLZ07_RS22720 (4638285) 4638285..4639439 - 1155 WP_023302389.1 lactonase family protein -
NLZ07_RS22725 (4639506) 4639506..4640246 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T250819 WP_002886902.1 NZ_CP100542:c4636042-4635758 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT250819 WP_002886901.1 NZ_CP100542:c4636274-4636032 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References