Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4538619..4539429 Replicon chromosome
Accession NZ_CP100542
Organism Klebsiella pneumoniae strain LH09-d

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag NLZ07_RS22300 Protein ID WP_040225378.1
Coordinates 4538619..4539152 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NLZ07_RS22305 Protein ID WP_002887278.1
Coordinates 4539163..4539429 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ07_RS22295 (4537450) 4537450..4538571 + 1122 WP_002887282.1 cupin domain-containing protein -
NLZ07_RS22300 (4538619) 4538619..4539152 - 534 WP_040225378.1 type II toxin-antitoxin system toxin KacT Toxin
NLZ07_RS22305 (4539163) 4539163..4539429 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NLZ07_RS22310 (4539532) 4539532..4540965 - 1434 WP_040225375.1 Cu(+)/Ag(+) sensor histidine kinase -
NLZ07_RS22315 (4540955) 4540955..4541638 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NLZ07_RS22320 (4541810) 4541810..4543192 + 1383 WP_040225374.1 efflux transporter outer membrane subunit -
NLZ07_RS22325 (4543210) 4543210..4543542 + 333 WP_025368487.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T250818 WP_040225378.1 NZ_CP100542:c4539152-4538619 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKVFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT250818 WP_002887278.1 NZ_CP100542:c4539429-4539163 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References