Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2554275..2555863 Replicon chromosome
Accession NZ_CP100542
Organism Klebsiella pneumoniae strain LH09-d

Toxin (Protein)


Gene name hipA Uniprot ID A0A485W5A2
Locus tag NLZ07_RS12580 Protein ID WP_023342812.1
Coordinates 2554275..2555597 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NLZ07_RS12585 Protein ID WP_024622638.1
Coordinates 2555597..2555863 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ07_RS12565 (2549331) 2549331..2551832 + 2502 WP_023342811.1 fimbria/pilus outer membrane usher protein -
NLZ07_RS12570 (2551820) 2551820..2552824 + 1005 WP_004224758.1 fimbrial protein -
NLZ07_RS12575 (2552966) 2552966..2554258 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NLZ07_RS12580 (2554275) 2554275..2555597 - 1323 WP_023342812.1 type II toxin-antitoxin system HipA family toxin Toxin
NLZ07_RS12585 (2555597) 2555597..2555863 - 267 WP_024622638.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NLZ07_RS12590 (2556128) 2556128..2556454 - 327 WP_004184023.1 hydroxyisourate hydrolase -
NLZ07_RS12595 (2556451) 2556451..2556951 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NLZ07_RS12600 (2556929) 2556929..2558308 - 1380 WP_032411468.1 nucleobase:cation symporter-2 family protein -
NLZ07_RS12605 (2558654) 2558654..2559808 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NLZ07_RS12610 (2559789) 2559789..2560712 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5358

>T250816 WP_023342812.1 NZ_CP100542:c2555597-2554275 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEVNAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9924.30 Da        Isoelectric Point: 8.5912

>AT250816 WP_024622638.1 NZ_CP100542:c2555863-2555597 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A485W5A2

Antitoxin

Source ID Structure

References