Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 786089..786746 Replicon chromosome
Accession NZ_CP100542
Organism Klebsiella pneumoniae strain LH09-d

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NLZ07_RS03920 Protein ID WP_002916310.1
Coordinates 786336..786746 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NLZ07_RS03915 Protein ID WP_002916312.1
Coordinates 786089..786355 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ07_RS03890 (781245) 781245..782678 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NLZ07_RS03895 (782797) 782797..783525 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NLZ07_RS03900 (783575) 783575..783886 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NLZ07_RS03905 (784050) 784050..784709 + 660 WP_002916317.1 hemolysin III family protein -
NLZ07_RS03910 (784860) 784860..785843 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
NLZ07_RS03915 (786089) 786089..786355 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NLZ07_RS03920 (786336) 786336..786746 + 411 WP_002916310.1 protein YgfX Toxin
NLZ07_RS03925 (786753) 786753..787274 - 522 WP_004144730.1 flavodoxin FldB -
NLZ07_RS03930 (787375) 787375..788271 + 897 WP_186593696.1 site-specific tyrosine recombinase XerD -
NLZ07_RS03935 (788294) 788294..789007 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NLZ07_RS03940 (789013) 789013..790746 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250811 WP_002916310.1 NZ_CP100542:786336-786746 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250811 WP_002916312.1 NZ_CP100542:786089-786355 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References