Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 42891..43450 Replicon plasmid pLH10-b-1-A
Accession NZ_CP100531
Organism Escherichia coli strain LH10-b-1

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag NLZ08_RS24335 Protein ID WP_000421257.1
Coordinates 42891..43166 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0H2XL20
Locus tag NLZ08_RS24340 Protein ID WP_012006537.1
Coordinates 43166..43450 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ08_RS24310 (NLZ08_24310) 39316..40550 + 1235 WP_089620070.1 IS3 family transposase -
NLZ08_RS24315 (NLZ08_24315) 40566..40823 - 258 Protein_43 DUF4158 domain-containing protein -
NLZ08_RS24320 (NLZ08_24320) 40990..41631 + 642 WP_052897785.1 recombinase family protein -
NLZ08_RS24325 (NLZ08_24325) 41678..42160 + 483 Protein_45 transposase -
NLZ08_RS24330 (NLZ08_24330) 42586..42785 - 200 Protein_46 hypothetical protein -
NLZ08_RS24335 (NLZ08_24335) 42891..43166 - 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ08_RS24340 (NLZ08_24340) 43166..43450 - 285 WP_012006537.1 ribbon-helix-helix domain-containing protein Antitoxin
NLZ08_RS24345 (NLZ08_24345) 43840..44850 + 1011 WP_096984501.1 IS110 family transposase -
NLZ08_RS24350 (NLZ08_24350) 45428..46018 + 591 WP_087599075.1 recombinase family protein -
NLZ08_RS24355 (NLZ08_24355) 46065..46223 + 159 Protein_51 integrase core domain-containing protein -
NLZ08_RS24360 (NLZ08_24360) 46373..47371 + 999 WP_000756335.1 ABC transporter substrate-binding protein -
NLZ08_RS24365 (NLZ08_24365) 47371..48408 + 1038 WP_000110580.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..169272 169272
- inside IScluster/Tn - - 39256..53437 14181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T250801 WP_000421257.1 NZ_CP100531:c43166-42891 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10501.96 Da        Isoelectric Point: 6.4632

>AT250801 WP_012006537.1 NZ_CP100531:c43450-43166 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVKSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2XL20

References