Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1822..2357 Replicon plasmid pLH10-b-1-A
Accession NZ_CP100531
Organism Escherichia coli strain LH10-b-1

Toxin (Protein)


Gene name relE Uniprot ID A0A0D8WEY8
Locus tag NLZ08_RS24115 Protein ID WP_032353555.1
Coordinates 2070..2357 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8WHE0
Locus tag NLZ08_RS24110 Protein ID WP_045145550.1
Coordinates 1822..2073 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ08_RS24100 (NLZ08_24100) 1..873 + 873 WP_045145554.1 incFII family plasmid replication initiator RepA -
NLZ08_RS24105 (NLZ08_24105) 1568..1735 + 168 WP_045145553.1 hypothetical protein -
NLZ08_RS24110 (NLZ08_24110) 1822..2073 + 252 WP_045145550.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NLZ08_RS24115 (NLZ08_24115) 2070..2357 + 288 WP_032353555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ08_RS24120 (NLZ08_24120) 2367..2654 + 288 WP_045145547.1 hypothetical protein -
NLZ08_RS24125 (NLZ08_24125) 3674..4261 + 588 WP_064550130.1 colanic acid biosynthesis acetyltransferase -
NLZ08_RS24130 (NLZ08_24130) 4541..5134 - 594 WP_208487633.1 ProQ/FINO family protein -
NLZ08_RS24135 (NLZ08_24135) 5988..7175 - 1188 WP_045145541.1 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..169272 169272


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11114.16 Da        Isoelectric Point: 10.6261

>T250800 WP_032353555.1 NZ_CP100531:2070-2357 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKAIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9219.48 Da        Isoelectric Point: 4.1789

>AT250800 WP_045145550.1 NZ_CP100531:1822-2073 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHYVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8WEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WHE0

References