Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 1486729..1487294 | Replicon | chromosome |
| Accession | NC_014965 | ||
| Organism | Vibrio vulnificus MO6-24/O | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | VVMO6_RS06855 | Protein ID | WP_031818843.1 |
| Coordinates | 1487007..1487294 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3BLE1 |
| Locus tag | VVMO6_RS06850 | Protein ID | WP_000086647.1 |
| Coordinates | 1486729..1487010 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VVMO6_RS06820 | 1481820..1482353 | + | 534 | WP_175546615.1 | adenylate kinase | - |
| VVMO6_RS22900 | 1482337..1482533 | + | 197 | Protein_1328 | DUF3265 domain-containing protein | - |
| VVMO6_RS22905 | 1482530..1482847 | - | 318 | WP_045596915.1 | YceK/YidQ family lipoprotein | - |
| VVMO6_RS22910 | 1482998..1483144 | + | 147 | WP_072612482.1 | DUF3265 domain-containing protein | - |
| VVMO6_RS06825 | 1483148..1483885 | + | 738 | WP_013571645.1 | hypothetical protein | - |
| VVMO6_RS06830 | 1484095..1484376 | + | 282 | WP_000086647.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| VVMO6_RS06835 | 1484373..1484660 | + | 288 | WP_005445239.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VVMO6_RS24135 | 1484688..1484780 | + | 93 | WP_080338837.1 | DUF3265 domain-containing protein | - |
| VVMO6_RS06840 | 1484811..1485269 | + | 459 | WP_130191685.1 | hypothetical protein | - |
| VVMO6_RS22920 | 1485266..1485388 | + | 123 | WP_072612579.1 | DUF3265 domain-containing protein | - |
| VVMO6_RS06845 | 1485447..1485935 | + | 489 | WP_013571648.1 | hypothetical protein | - |
| VVMO6_RS22925 | 1485935..1486171 | + | 237 | WP_086016874.1 | DUF3265 domain-containing protein | - |
| VVMO6_RS06850 | 1486729..1487010 | + | 282 | WP_000086647.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VVMO6_RS06855 | 1487007..1487294 | + | 288 | WP_031818843.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VVMO6_RS24190 | 1487304..1487423 | + | 120 | Protein_1341 | DUF3265 domain-containing protein | - |
| VVMO6_RS06860 | 1487448..1487819 | + | 372 | WP_013571650.1 | hypothetical protein | - |
| VVMO6_RS06865 | 1487965..1488294 | + | 330 | WP_044023851.1 | hypothetical protein | - |
| VVMO6_RS06870 | 1488471..1489841 | + | 1371 | WP_013571652.1 | hypothetical protein | - |
| VVMO6_RS06875 | 1489978..1490445 | + | 468 | WP_013571653.1 | hypothetical protein | - |
| VVMO6_RS22935 | 1490452..1490583 | + | 132 | WP_080557481.1 | DUF3265 domain-containing protein | - |
| VVMO6_RS06880 | 1490576..1490905 | + | 330 | WP_013571654.1 | hypothetical protein | - |
| VVMO6_RS22940 | 1490878..1491039 | + | 162 | WP_013571655.1 | DUF3265 domain-containing protein | - |
| VVMO6_RS24275 | 1491380..1491523 | + | 144 | Protein_1349 | DUF3265 domain-containing protein | - |
| VVMO6_RS23915 | 1491866..1491988 | + | 123 | WP_085761468.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | flp1 / VP1611 | 1185032..1724682 | 539650 | |
| - | inside | Integron | - | - | 1434218..1558944 | 124726 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11017.72 Da Isoelectric Point: 5.6096
>T25080 WP_031818843.1 NC_014965:1487007-1487294 [Vibrio vulnificus MO6-24/O]
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRI
LTVRNCRQILSESDV
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRI
LTVRNCRQILSESDV
Download Length: 288 bp
>T25080 NC_014965:1487007-1487294 [Vibrio vulnificus MO6-24/O]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
GGCAGAGAGGTGGGTAAACGAAGTTTTTGATAAAACTGAACTCCTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCATACGAATTATCGCGAAATCATCTTTGGCCACTACCGTATTATCTACAGTTTAAGCCACGAAATTCGCATA
CTAACAGTTCGTAACTGTCGTCAAATTTTATCTGAAAGTGACGTGTAA
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
GGCAGAGAGGTGGGTAAACGAAGTTTTTGATAAAACTGAACTCCTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCATACGAATTATCGCGAAATCATCTTTGGCCACTACCGTATTATCTACAGTTTAAGCCACGAAATTCGCATA
CTAACAGTTCGTAACTGTCGTCAAATTTTATCTGAAAGTGACGTGTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10398.91 Da Isoelectric Point: 5.8650
>AT25080 WP_000086647.1 NC_014965:1486729-1487010 [Vibrio vulnificus MO6-24/O]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK
Download Length: 282 bp
>AT25080 NC_014965:1486729-1487010 [Vibrio vulnificus MO6-24/O]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAGATGCGCACAGCTGAAGCTCAATTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAGAAATGA
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAGATGCGCACAGCTGAAGCTCAATTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|