Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4374164..4374661 Replicon chromosome
Accession NZ_CP100530
Organism Escherichia coli strain LH10-b-1

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NLZ08_RS21490 Protein ID WP_001173343.1
Coordinates 4374164..4374337 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NLZ08_RS21495 Protein ID WP_000398619.1
Coordinates 4374365..4374661 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ08_RS21480 (4370834) 4370834..4372291 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
NLZ08_RS21485 (4372528) 4372528..4374045 + 1518 WP_001295090.1 lysine--tRNA ligase -
NLZ08_RS21490 (4374164) 4374164..4374337 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NLZ08_RS21495 (4374365) 4374365..4374661 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NLZ08_RS21500 (4374888) 4374888..4375160 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
NLZ08_RS21505 (4375172) 4375172..4375402 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
NLZ08_RS21510 (4375583) 4375583..4377214 + 1632 WP_001216477.1 sensor histidine kinase -
NLZ08_RS21515 (4377211) 4377211..4377930 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T250799 WP_001173343.1 NZ_CP100530:c4374337-4374164 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT250799 WP_000398619.1 NZ_CP100530:c4374661-4374365 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References