Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3640329..3640947 Replicon chromosome
Accession NZ_CP100530
Organism Escherichia coli strain LH10-b-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NLZ08_RS18005 Protein ID WP_001291435.1
Coordinates 3640729..3640947 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NLZ08_RS18000 Protein ID WP_000344800.1
Coordinates 3640329..3640703 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ08_RS17990 (3635418) 3635418..3636611 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NLZ08_RS17995 (3636634) 3636634..3639783 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NLZ08_RS18000 (3640329) 3640329..3640703 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NLZ08_RS18005 (3640729) 3640729..3640947 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NLZ08_RS18010 (3641119) 3641119..3641670 + 552 WP_000102564.1 maltose O-acetyltransferase -
NLZ08_RS18015 (3641786) 3641786..3642256 + 471 WP_000136192.1 YlaC family protein -
NLZ08_RS18020 (3642420) 3642420..3643970 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NLZ08_RS18025 (3644012) 3644012..3644365 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NLZ08_RS18035 (3644744) 3644744..3645055 + 312 WP_000409911.1 MGMT family protein -
NLZ08_RS18040 (3645086) 3645086..3645658 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T250791 WP_001291435.1 NZ_CP100530:3640729-3640947 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT250791 WP_000344800.1 NZ_CP100530:3640329-3640703 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References