Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 834459..835294 | Replicon | chromosome |
| Accession | NZ_CP100530 | ||
| Organism | Escherichia coli strain LH10-b-1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | NLZ08_RS04015 | Protein ID | WP_029402447.1 |
| Coordinates | 834459..834836 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3Z2YIX3 |
| Locus tag | NLZ08_RS04020 | Protein ID | WP_032178229.1 |
| Coordinates | 834926..835294 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NLZ08_RS03980 (829883) | 829883..830118 | - | 236 | Protein_782 | IS110 family transposase | - |
| NLZ08_RS03985 (830702) | 830702..831967 | - | 1266 | WP_001697401.1 | integrase arm-type DNA-binding domain-containing protein | - |
| NLZ08_RS03990 (832431) | 832431..832757 | - | 327 | WP_000779482.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| NLZ08_RS03995 (832754) | 832754..833017 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| NLZ08_RS04000 (833089) | 833089..833955 | - | 867 | WP_024257423.1 | DUF4942 domain-containing protein | - |
| NLZ08_RS04005 (834040) | 834040..834237 | - | 198 | WP_097471913.1 | DUF957 domain-containing protein | - |
| NLZ08_RS04010 (834313) | 834313..834462 | - | 150 | Protein_788 | DUF5983 family protein | - |
| NLZ08_RS04015 (834459) | 834459..834836 | - | 378 | WP_029402447.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| NLZ08_RS04020 (834926) | 834926..835294 | - | 369 | WP_032178229.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| NLZ08_RS04025 (835344) | 835344..835988 | - | 645 | WP_060615859.1 | hypothetical protein | - |
| NLZ08_RS04030 (836007) | 836007..836228 | - | 222 | WP_029402821.1 | DUF987 domain-containing protein | - |
| NLZ08_RS04035 (836297) | 836297..836773 | - | 477 | WP_001186771.1 | RadC family protein | - |
| NLZ08_RS04040 (836789) | 836789..837274 | - | 486 | WP_071045790.1 | antirestriction protein | - |
| NLZ08_RS04045 (837366) | 837366..838184 | - | 819 | WP_024214765.1 | DUF932 domain-containing protein | - |
| NLZ08_RS04050 (838274) | 838274..838483 | - | 210 | WP_032150870.1 | DUF905 family protein | - |
| NLZ08_RS04055 (838513) | 838513..839190 | - | 678 | WP_001097301.1 | hypothetical protein | - |
| NLZ08_RS04060 (839338) | 839338..840018 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13900.92 Da Isoelectric Point: 8.5163
>T250780 WP_029402447.1 NZ_CP100530:c834836-834459 [Escherichia coli]
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T250780 NZ_CP100530:c834836-834459 [Escherichia coli]
ATGAAAACATTGCCTGTATTACCCGGGCAGGCGGCCGGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTTAC
CAGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTGCCTGTATTACCCGGGCAGGCGGCCGGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTTAC
CAGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13823.58 Da Isoelectric Point: 6.3177
>AT250780 WP_032178229.1 NZ_CP100530:c835294-834926 [Escherichia coli]
VSDTLHETNYPDDNNDRSWWGLPCTVTPCFRARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLHETNYPDDNNDRSWWGLPCTVTPCFRARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT250780 NZ_CP100530:c835294-834926 [Escherichia coli]
GTGTCAGACACACTCCATGAAACAAATTATCCCGACGACAACAACGACCGCTCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCAGGGCACGTCTGGTGCAGGAAGGGAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGTCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCATGAAACAAATTATCCCGACGACAACAACGACCGCTCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCAGGGCACGTCTGGTGCAGGAAGGGAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGTCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|