Detailed information of TA system TA025078

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1474453..1475018
• Replicon: chromosome
• Accession: NC_014965
• Organism: Vibrio vulnificus MO6-24/O

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VVMO6_RS06780
• Protein ID: WP_013571636.1
• Coordinates: 1474731..1475018 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3NI65
• Locus tag: VVMO6_RS06775
• Protein ID: WP_011080399.1
• Coordinates: 1474453..1474734 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VVMO6_RS06750	1469836..1470444	+	609	WP_044023847.1	pyridoxamine 5'-phosphate oxidase family protein	-
VVMO6_RS06755	1470590..1471195	+	606	WP_013571632.1	hypothetical protein	-
VVMO6_RS22855	1471664..1471786	+	123	WP_072612483.1	DUF3265 domain-containing protein	-
VVMO6_RS06760	1471803..1472318	+	516	WP_013571633.1	GNAT family N-acetyltransferase	-
VVMO6_RS22860	1472319..1472447	+	129	WP_072612484.1	DUF3265 domain-containing protein	-
VVMO6_RS06765	1472463..1473038	+	576	WP_013571634.1	hypothetical protein	-
VVMO6_RS22865	1473056..1473145	+	90	WP_193387242.1	DUF3265 domain-containing protein	-
VVMO6_RS06770	1473593..1474255	+	663	WP_044023848.1	hypothetical protein	-
VVMO6_RS22870	1474270..1474362	+	93	WP_192947844.1	DUF3265 domain-containing protein	-
VVMO6_RS06775	1474453..1474734	+	282	WP_011080399.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VVMO6_RS06780	1474731..1475018	+	288	WP_013571636.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VVMO6_RS06785	1475164..1475517	+	354	WP_044023849.1	hypothetical protein	-
VVMO6_RS06790	1475632..1476768	-	1137	WP_013571638.1	Abi family protein	-
VVMO6_RS22875	1477341..1477505	+	165	WP_080557479.1	DUF3265 domain-containing protein	-
VVMO6_RS06800	1478069..1478566	+	498	WP_013571640.1	DUF2867 domain-containing protein	-
VVMO6_RS22880	1478563..1478685	+	123	Protein_1320	DUF3265 domain-containing protein	-
VVMO6_RS06805	1478699..1479388	+	690	WP_044023850.1	hypothetical protein	-
VVMO6_RS23640	1479385..1479513	+	129	Protein_1322	DUF3265 domain-containing protein	-
VVMO6_RS22890	1479863..1480009	+	147	WP_072612485.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	flp1 / VP1611	1185032..1724682	539650
	-	inside	Integron	-	-	1434218..1558944	124726

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11014.71 Da
• Isoelectric Point: 5.0872

>T25078 WP_013571636.1 NC_014965:1474731-1475018 [Vibrio vulnificus MO6-24/O]
MKVVWSPLALQKLGDAAEFISLDNPVAAENWVNEVFDKTELLSNMPEMGRMIPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQILTESDV

Nucleotide

• Length: 288 bp

>T25078 NC_014965:1474731-1475018 [Vibrio vulnificus MO6-24/O]
ATGAAAGTAGTCTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCCGAGTTTATTTCATTGGATAACCCAGTGGC
AGCAGAAAACTGGGTTAACGAGGTTTTCGATAAAACCGAGCTTCTCTCAAATATGCCTGAAATGGGGCGAATGATTCCTG
AGCTGCCTCATACCAATTACCGCGAAATTTTGTTTGGTCACTATCGCATCATATATAGTCTTAGCCATGAAATTCGCGTC
CTCACAGTACGAAATTGTCGTCAGATACTAACGGAAAGTGACGTGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10426.96 Da
• Isoelectric Point: 5.8719

>AT25078 WP_011080399.1 NC_014965:1474453-1474734 [Vibrio vulnificus MO6-24/O]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT25078 NC_014965:1474453-1474734 [Vibrio vulnificus MO6-24/O]
ATGAGCCGTATCCACTTTGACCAAGATATTCAGCCTTTGTCTGAATTTCGTGCTGGCGTAACGTCATTTATTAAACAGAT
TAACGAAACTCGCAGACCATTGGTAATCACACAGCGTGGTAAGGGTGTTGCGGTTGTCCTTGATGTTGCGGAATATGAAG
CAATGCAAGAGAAGATCGAGTTACTGGAAGAAATGCGTACTGCTGAAGCACAGTTAGCTTCAGGTTTAGGTGTTTCCAAT
GAAGACGCTCGTGCTCAAGTGTTGGGGCGTATCAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3S0MQY5