Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 8735..9270 Replicon plasmid pLH13-b-B
Accession NZ_CP100527
Organism Escherichia coli strain LH13-b

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag NLZ09_RS23365 Protein ID WP_000222771.1
Coordinates 8735..9022 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag NLZ09_RS23370 Protein ID WP_001139206.1
Coordinates 9019..9270 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ09_RS23350 (NLZ09_23350) 4360..7875 + 3516 WP_094321081.1 autotransporter outer membrane beta-barrel domain-containing protein -
NLZ09_RS23355 (NLZ09_23355) 8050..8255 - 206 Protein_6 hypothetical protein -
NLZ09_RS23360 (NLZ09_23360) 8254..8367 + 114 Protein_7 alkaline phosphatase -
NLZ09_RS23365 (NLZ09_23365) 8735..9022 - 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ09_RS23370 (NLZ09_23370) 9019..9270 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NLZ09_RS23375 (NLZ09_23375) 9883..11700 + 1818 Protein_10 helicase -
NLZ09_RS23380 (NLZ09_23380) 11734..12174 + 441 WP_023352064.1 hypothetical protein -
NLZ09_RS23385 (NLZ09_23385) 12171..12419 + 249 WP_000747846.1 hypothetical protein -
NLZ09_RS23390 (NLZ09_23390) 12458..13179 - 722 Protein_13 helix-turn-helix domain-containing protein -
NLZ09_RS23395 (NLZ09_23395) 13414..14103 + 690 WP_000452096.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..80637 80637


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T250774 WP_000222771.1 NZ_CP100527:c9022-8735 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT250774 WP_001139206.1 NZ_CP100527:c9270-9019 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References