Detailed information of TA system TA025077

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1455611..1456170
• Replicon: chromosome
• Accession: NC_014965
• Organism: Vibrio vulnificus MO6-24/O

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VVMO6_RS06655
• Protein ID: WP_013571609.1
• Coordinates: 1455611..1455889 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: VVMO6_RS06660
• Protein ID: WP_013571610.1
• Coordinates: 1455886..1456170 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VVMO6_RS06630	1450721..1451341	+	621	WP_013571605.1	hypothetical protein	-
VVMO6_RS24130	1451486..1452013	+	528	WP_013571599.1	hypothetical protein	-
VVMO6_RS06640	1453068..1453385	+	318	WP_044023840.1	hypothetical protein	-
VVMO6_RS06645	1453994..1454578	+	585	WP_052299106.1	hypothetical protein	-
VVMO6_RS22760	1454724..1454834	+	111	WP_072612519.1	DUF3265 domain-containing protein	-
VVMO6_RS06650	1454863..1455474	+	612	WP_044023841.1	hypothetical protein	-
VVMO6_RS23615	1455441..1455593	+	153	WP_086016871.1	DUF3265 domain-containing protein	-
VVMO6_RS06655	1455611..1455889	-	279	WP_013571609.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
VVMO6_RS06660	1455886..1456170	-	285	WP_013571610.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
VVMO6_RS22770	1456169..1456351	+	183	WP_072612510.1	DUF3265 domain-containing protein	-
VVMO6_RS24185	1456537..1456708	+	172	Protein_1276	DUF645 family protein	-
VVMO6_RS06675	1456905..1457648	+	744	WP_013571612.1	hypothetical protein	-
VVMO6_RS06680	1457794..1458207	+	414	WP_013571613.1	GNAT family N-acetyltransferase	-
VVMO6_RS06685	1458405..1458773	+	369	WP_013571614.1	VOC family protein	-
VVMO6_RS23870	1459281..1459382	+	102	WP_110178353.1	DUF3265 domain-containing protein	-
VVMO6_RS06690	1459847..1460272	+	426	WP_013571617.1	hypothetical protein	-
VVMO6_RS22790	1460260..1460397	+	138	WP_072612518.1	DUF3265 domain-containing protein	-
VVMO6_RS22795	1460726..1460861	+	136	Protein_1283	DUF3265 domain-containing protein	-
VVMO6_RS06695	1460878..1461159	+	282	WP_044023843.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	flp1 / VP1611	1185032..1724682	539650
	-	inside	Integron	-	-	1434218..1558944	124726

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-75)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10970.64 Da
• Isoelectric Point: 4.3697

>T25077 WP_013571609.1 NC_014965:c1455889-1455611 [Vibrio vulnificus MO6-24/O]
MILWEEESLNDREKIFEFLHDFNPDAAERTDEIIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGDFIRIM
RVLHQKQKFPVD

Nucleotide

• Length: 279 bp

>T25077 NC_014965:c1455889-1455611 [Vibrio vulnificus MO6-24/O]
ATGATTTTGTGGGAAGAAGAGTCTCTGAACGATCGTGAAAAGATCTTTGAGTTTCTTCATGATTTCAACCCTGACGCTGC
AGAAAGAACTGACGAGATCATCGAAACAAAAGTTGAAAACCTGTTAGAGCAACCTCTTATGGGGGTACAACGTGACGGGA
TCAGAGGGCGATTGCTCATCATTCCTGAAATATCGATGATCGTATCCTATTGGGTCGACGGTGACTTTATTCGCATAATG
CGTGTACTACACCAAAAGCAAAAGTTCCCGGTGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10937.36 Da
• Isoelectric Point: 9.1865

>AT25077 WP_013571610.1 NC_014965:c1456170-1455886 [Vibrio vulnificus MO6-24/O]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKAVFVDHESAKVR
MAERKAKIRNRGKL

Nucleotide

• Length: 285 bp

>AT25077 NC_014965:c1456170-1455886 [Vibrio vulnificus MO6-24/O]
ATGGACACCAGAATTCAGTTTCGTGTTGATGAAGAAACTAAACGACTAGCTCAACAAATGGCTGAAAGCCAAGGCAGAAC
ATTGAGTGATGCTTGCCGAGAATTGACTGAGCAACTAGCAGAACAACAGAGAAAGACCTTATCTCACGATGCATGGTTAA
CTGAACAAGTAAATTTGGCTTTTGAGAAGTTCGATTCAGGGAAAGCCGTTTTTGTTGACCACGAATCAGCAAAAGTTCGT
ATGGCCGAGCGCAAAGCTAAAATTCGCAACCGAGGCAAATTATGA