Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1455611..1456170 Replicon chromosome
Accession NC_014965
Organism Vibrio vulnificus MO6-24/O

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag VVMO6_RS06655 Protein ID WP_013571609.1
Coordinates 1455611..1455889 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag VVMO6_RS06660 Protein ID WP_013571610.1
Coordinates 1455886..1456170 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VVMO6_RS06630 1450721..1451341 + 621 WP_013571605.1 hypothetical protein -
VVMO6_RS24130 1451486..1452013 + 528 WP_013571599.1 hypothetical protein -
VVMO6_RS06640 1453068..1453385 + 318 WP_044023840.1 hypothetical protein -
VVMO6_RS06645 1453994..1454578 + 585 WP_052299106.1 hypothetical protein -
VVMO6_RS22760 1454724..1454834 + 111 WP_072612519.1 DUF3265 domain-containing protein -
VVMO6_RS06650 1454863..1455474 + 612 WP_044023841.1 hypothetical protein -
VVMO6_RS23615 1455441..1455593 + 153 WP_086016871.1 DUF3265 domain-containing protein -
VVMO6_RS06655 1455611..1455889 - 279 WP_013571609.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
VVMO6_RS06660 1455886..1456170 - 285 WP_013571610.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VVMO6_RS22770 1456169..1456351 + 183 WP_072612510.1 DUF3265 domain-containing protein -
VVMO6_RS24185 1456537..1456708 + 172 Protein_1276 DUF645 family protein -
VVMO6_RS06675 1456905..1457648 + 744 WP_013571612.1 hypothetical protein -
VVMO6_RS06680 1457794..1458207 + 414 WP_013571613.1 GNAT family N-acetyltransferase -
VVMO6_RS06685 1458405..1458773 + 369 WP_013571614.1 VOC family protein -
VVMO6_RS23870 1459281..1459382 + 102 WP_110178353.1 DUF3265 domain-containing protein -
VVMO6_RS06690 1459847..1460272 + 426 WP_013571617.1 hypothetical protein -
VVMO6_RS22790 1460260..1460397 + 138 WP_072612518.1 DUF3265 domain-containing protein -
VVMO6_RS22795 1460726..1460861 + 136 Protein_1283 DUF3265 domain-containing protein -
VVMO6_RS06695 1460878..1461159 + 282 WP_044023843.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flp1 / VP1611 1185032..1724682 539650
- inside Integron - - 1434218..1558944 124726


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10970.64 Da        Isoelectric Point: 4.3697

>T25077 WP_013571609.1 NC_014965:c1455889-1455611 [Vibrio vulnificus MO6-24/O]
MILWEEESLNDREKIFEFLHDFNPDAAERTDEIIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGDFIRIM
RVLHQKQKFPVD

Download         Length: 279 bp

>T25077 NC_014965:c1455889-1455611 [Vibrio vulnificus MO6-24/O]
ATGATTTTGTGGGAAGAAGAGTCTCTGAACGATCGTGAAAAGATCTTTGAGTTTCTTCATGATTTCAACCCTGACGCTGC
AGAAAGAACTGACGAGATCATCGAAACAAAAGTTGAAAACCTGTTAGAGCAACCTCTTATGGGGGTACAACGTGACGGGA
TCAGAGGGCGATTGCTCATCATTCCTGAAATATCGATGATCGTATCCTATTGGGTCGACGGTGACTTTATTCGCATAATG
CGTGTACTACACCAAAAGCAAAAGTTCCCGGTGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10937.36 Da        Isoelectric Point: 9.1865

>AT25077 WP_013571610.1 NC_014965:c1456170-1455886 [Vibrio vulnificus MO6-24/O]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKAVFVDHESAKVR
MAERKAKIRNRGKL

Download         Length: 285 bp

>AT25077 NC_014965:c1456170-1455886 [Vibrio vulnificus MO6-24/O]
ATGGACACCAGAATTCAGTTTCGTGTTGATGAAGAAACTAAACGACTAGCTCAACAAATGGCTGAAAGCCAAGGCAGAAC
ATTGAGTGATGCTTGCCGAGAATTGACTGAGCAACTAGCAGAACAACAGAGAAAGACCTTATCTCACGATGCATGGTTAA
CTGAACAAGTAAATTTGGCTTTTGAGAAGTTCGATTCAGGGAAAGCCGTTTTTGTTGACCACGAATCAGCAAAAGTTCGT
ATGGCCGAGCGCAAAGCTAAAATTCGCAACCGAGGCAAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References