Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4084504..4085099 Replicon chromosome
Accession NZ_CP100525
Organism Escherichia coli strain LH13-b

Toxin (Protein)


Gene name chpB Uniprot ID A0A827ISR3
Locus tag NLZ09_RS19970 Protein ID WP_061359519.1
Coordinates 4084504..4084854 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A240D6C8
Locus tag NLZ09_RS19975 Protein ID WP_001223212.1
Coordinates 4084848..4085099 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ09_RS19950 (4079952) 4079952..4080974 - 1023 WP_001301928.1 ABC transporter permease -
NLZ09_RS19955 (4080988) 4080988..4082491 - 1504 Protein_3903 sugar ABC transporter ATP-binding protein -
NLZ09_RS19960 (4082631) 4082631..4083587 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NLZ09_RS19965 (4083897) 4083897..4084427 + 531 WP_000055070.1 inorganic diphosphatase -
NLZ09_RS19970 (4084504) 4084504..4084854 - 351 WP_061359519.1 endoribonuclease toxin ChpB Toxin
NLZ09_RS19975 (4084848) 4084848..4085099 - 252 WP_001223212.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NLZ09_RS19980 (4085311) 4085311..4085652 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NLZ09_RS19985 (4085655) 4085655..4089434 - 3780 WP_061359518.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12506.43 Da        Isoelectric Point: 6.4786

>T250768 WP_061359519.1 NZ_CP100525:c4084854-4084504 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARQAKRIGLAADEVVEEALLRLQAVVK

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9301.61 Da        Isoelectric Point: 4.6509

>AT250768 WP_001223212.1 NZ_CP100525:c4085099-4084848 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A827ISR3

Antitoxin

Source ID Structure
AlphaFold DB A0A240D6C8

References