Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3415307..3415925 Replicon chromosome
Accession NZ_CP100525
Organism Escherichia coli strain LH13-b

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NLZ09_RS16655 Protein ID WP_001291435.1
Coordinates 3415707..3415925 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NLZ09_RS16650 Protein ID WP_000344800.1
Coordinates 3415307..3415681 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ09_RS16640 (3410396) 3410396..3411589 + 1194 WP_254541811.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NLZ09_RS16645 (3411612) 3411612..3414761 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NLZ09_RS16650 (3415307) 3415307..3415681 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NLZ09_RS16655 (3415707) 3415707..3415925 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NLZ09_RS16660 (3416097) 3416097..3416648 + 552 WP_000102564.1 maltose O-acetyltransferase -
NLZ09_RS16665 (3416764) 3416764..3417234 + 471 WP_000136192.1 YlaC family protein -
NLZ09_RS16670 (3417398) 3417398..3418948 + 1551 WP_014639849.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NLZ09_RS16675 (3418990) 3418990..3419343 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NLZ09_RS16685 (3419722) 3419722..3420033 + 312 WP_000409911.1 MGMT family protein -
NLZ09_RS16690 (3420064) 3420064..3420636 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T250764 WP_001291435.1 NZ_CP100525:3415707-3415925 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT250764 WP_000344800.1 NZ_CP100525:3415307-3415681 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References