Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2373754..2374392 Replicon chromosome
Accession NZ_CP100525
Organism Escherichia coli strain LH13-b

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NLZ09_RS11550 Protein ID WP_000813794.1
Coordinates 2374216..2374392 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NLZ09_RS11545 Protein ID WP_001270286.1
Coordinates 2373754..2374170 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ09_RS11525 (2368906) 2368906..2369847 - 942 WP_001251313.1 ABC transporter permease -
NLZ09_RS11530 (2369848) 2369848..2370861 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
NLZ09_RS11535 (2370879) 2370879..2372024 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NLZ09_RS11540 (2372269) 2372269..2373675 - 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
NLZ09_RS11545 (2373754) 2373754..2374170 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NLZ09_RS11550 (2374216) 2374216..2374392 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NLZ09_RS11555 (2374614) 2374614..2374844 + 231 WP_154813306.1 YncJ family protein -
NLZ09_RS11560 (2374936) 2374936..2376897 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NLZ09_RS11565 (2376970) 2376970..2377506 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
NLZ09_RS11570 (2377598) 2377598..2378773 + 1176 WP_001236251.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2378813..2380078 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T250763 WP_000813794.1 NZ_CP100525:c2374392-2374216 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT250763 WP_001270286.1 NZ_CP100525:c2374170-2373754 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References