Detailed information of TA system TA025076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1022793..1024354
• Replicon: chromosome
• Accession: NC_014965
• Organism: Vibrio vulnificus MO6-24/O

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: VVMO6_RS04850
• Protein ID: WP_013571357.1
• Coordinates: 1023026..1024354 (+)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: VVMO6_RS04845
• Protein ID: WP_013571356.1
• Coordinates: 1022793..1023032 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VVMO6_RS04830	1019780..1019965	+	186	WP_044023812.1	hypothetical protein	-
VVMO6_RS04835	1019977..1020450	+	474	WP_013571354.1	hypothetical protein	-
VVMO6_RS04840	1020947..1022245	-	1299	WP_013571355.1	deoxyguanosinetriphosphate triphosphohydrolase family protein	-
VVMO6_RS04845	1022793..1023032	+	240	WP_013571356.1	helix-turn-helix domain-containing protein	Antitoxin
VVMO6_RS04850	1023026..1024354	+	1329	WP_013571357.1	type II toxin-antitoxin system HipA family toxin	Toxin
VVMO6_RS04855	1024603..1025925	-	1323	WP_013571358.1	site-specific integrase	-
VVMO6_RS04860	1026742..1027377	+	636	WP_013571359.1	magnesium transporter	-
VVMO6_RS04865	1027515..1028567	+	1053	WP_013571360.1	GGDEF domain-containing protein	-
VVMO6_RS04870	1028768..1029232	+	465	WP_011079944.1	DUF2846 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1002114..1025925	23811

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-399)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-55)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49654.95 Da
• Isoelectric Point: 8.8512

>T25076 WP_013571357.1 NC_014965:1023026-1024354 [Vibrio vulnificus MO6-24/O]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSGWISASNSRPISLSMPLRKDAYTGSEVINFFDNLLPDNQQIRDRIAARY
KADTKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRTITAKALSEKELVRILKGYMEDAPLGMLKEEDDFRISIAGAQEKT
ALLFYDGRWMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDR
KLSSDNSYYLRLPHEDFCQAKGIPSARKYEIDGGIGIEESIDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLAGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
STTMAVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Nucleotide

• Length: 1329 bp

>T25076 NC_014965:1023026-1024354 [Vibrio vulnificus MO6-24/O]
ATGGTGAATCGACTTCATGCTTACATGAATGGCGTAAAGGTTGGGGTACTTGAAAAGCGAACAAACGGCGCACATGTTTT
CACTTACGATTCGGGCTGGATTTCAGCATCAAATAGTCGCCCTATCTCGCTTTCTATGCCTCTCAGGAAGGATGCGTATA
CTGGCAGTGAGGTTATTAACTTCTTTGATAACTTACTGCCAGATAATCAGCAGATACGAGATAGAATAGCTGCTCGCTAT
AAAGCAGATACTAAACAGCCATTTGACCTATTAGCTAAGGTTGGTCGAGATGCTGTAGGTGCTATCACGCTAGTTCCAGA
GGGTTTTGATGTAGATGATCATCGAACCATAACCGCAAAGGCGTTATCCGAAAAGGAATTGGTTAGAATCCTAAAGGGAT
ATATGGAGGACGCTCCTTTGGGGATGCTGAAAGAGGAAGATGATTTTAGGATCTCGATAGCGGGAGCGCAGGAAAAGACA
GCCTTACTGTTCTACGATGGAAGATGGATGCTACCACAGGGAATGACTCCAACTACGCATATTATCAAGCTGCCAATAGG
TGAAATTGTTTCTCAGAACAATGTTATTGATTTGTCTGCTAGTGTAGATAATGAGTTGATTTGTATGAGGCTAGCAAAGG
CGTTCGGCATTCAAACGGCAAACTGTGACATTATTCGTGCTGGTGATGTTCGTGCCTTGTCTGTTGAGCGATTTGACCGA
AAATTATCTTCTGATAACAGCTATTACTTGCGCTTGCCCCATGAGGATTTTTGCCAGGCAAAAGGGATTCCCTCAGCTAG
AAAATATGAAATTGACGGTGGTATCGGCATAGAAGAATCTATTGATATTTTGCGATACTCATACGAAATCAACGATACCG
TTACTTTTGCACGTTCTCAGATATTGTTTTGGCTACTAGCTGCCATTGACGGGCATGGAAAGAATTTCTCTGTAAGTATA
GCCGCATCTGGTCGATATCAGCTTGCACCACTGTATGACATTATTTCGGCACATCCACTGGCAGGTGGGCGTGGTTTGAG
TGAGCGTAAGATCAAGATGGCAATGAGCTTACGTGGTACTAGTGGTCGAAAATGGAAGTGGCACCAACTTCAACCGCGCC
ATTTCGAAGATACCTTTCACACTATGAACGTCCCGAATATAAGGCGAGAAAAGGTTCGCTTATTGCTTGATGAGTTTGAA
TCGACGACAATGGCGGTGATTGATTCTGTCGGAAACTCGCTACCAACTGATATCAACGAAAGCGTAAGAGATAAAATATT
TAACGGTGTCTTAAAGACCGTCAAGAAGATTCAATTGACAAAAAAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8718.90 Da
• Isoelectric Point: 5.6664

>AT25076 WP_013571356.1 NC_014965:1022793-1023032 [Vibrio vulnificus MO6-24/O]
MLVNTPTALGNALREARKDNGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGEHITETKGAVDEW

Nucleotide

• Length: 240 bp

>AT25076 NC_014965:1022793-1023032 [Vibrio vulnificus MO6-24/O]
ATGCTAGTCAACACACCGACAGCCCTCGGCAATGCGTTACGCGAAGCCCGAAAGGACAACGGCCTAAAGCAAACAGATCT
TGGTCTGCGGCAAGCAACGGTATCAAATTTTGAAAGCAACCCTGAAAAATCCACGATAGAAACATTATTCAAGCTCCTGT
CCATCAATGGGCTAGAAATGCATATTGTGCCTAAAGGCGAGCACATTACTGAAACTAAAGGGGCTGTTGACGAATGGTGA