Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 972939..973522 Replicon chromosome
Accession NZ_CP100525
Organism Escherichia coli strain LH13-b

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NLZ09_RS04720 Protein ID WP_136699239.1
Coordinates 973187..973522 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag NLZ09_RS04715 Protein ID WP_000581937.1
Coordinates 972939..973187 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ09_RS04705 (969278) 969278..970579 + 1302 WP_136699240.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
NLZ09_RS04710 (970627) 970627..972861 + 2235 WP_000226815.1 GTP pyrophosphokinase -
NLZ09_RS04715 (972939) 972939..973187 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NLZ09_RS04720 (973187) 973187..973522 + 336 WP_136699239.1 endoribonuclease MazF Toxin
NLZ09_RS04725 (973593) 973593..974384 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
NLZ09_RS04730 (974612) 974612..976249 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
NLZ09_RS04735 (976337) 976337..977635 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12088.00 Da        Isoelectric Point: 8.2618

>T250757 WP_136699239.1 NZ_CP100525:973187-973522 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVSCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT250757 WP_000581937.1 NZ_CP100525:972939-973187 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References