Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 127415..128166 Replicon plasmid pLH13-d-A
Accession NZ_CP100521
Organism Klebsiella pneumoniae strain LH13-d

Toxin (Protein)


Gene name ataT Uniprot ID A0A6P1V716
Locus tag NLZ10_RS25860 Protein ID WP_048978473.1
Coordinates 127415..127897 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6P1V8A4
Locus tag NLZ10_RS25865 Protein ID WP_048978474.1
Coordinates 127888..128166 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ10_RS25845 (NLZ10_25845) 124577..125545 + 969 Protein_139 IS5 family transposase -
NLZ10_RS25850 (NLZ10_25850) 125857..126825 + 969 WP_163354964.1 IS5-like element IS903B family transposase -
NLZ10_RS25855 (NLZ10_25855) 126973..127377 - 405 WP_004210282.1 DUF2251 domain-containing protein -
NLZ10_RS25860 (NLZ10_25860) 127415..127897 - 483 WP_048978473.1 GNAT family N-acetyltransferase Toxin
NLZ10_RS25865 (NLZ10_25865) 127888..128166 - 279 WP_048978474.1 DUF1778 domain-containing protein Antitoxin
NLZ10_RS25870 (NLZ10_25870) 130018..130332 + 315 WP_032435789.1 hypothetical protein -
NLZ10_RS25875 (NLZ10_25875) 130575..131057 - 483 WP_171996278.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..224507 224507


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17763.69 Da        Isoelectric Point: 9.4946

>T250752 WP_048978473.1 NZ_CP100521:c127897-127415 [Klebsiella pneumoniae]
MGLRPPEPLTPEHNIAEFCCQDQVLSEWLKKKALKNHRTGISRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTEHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10694.21 Da        Isoelectric Point: 4.5038

>AT250752 WP_048978474.1 NZ_CP100521:c128166-127888 [Klebsiella pneumoniae]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDNQFNAFVEELDAPMTPERQAR
IDNLMSRKSPWD

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1V716

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8A4

References