Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 47695..48221 Replicon plasmid pLH13-d-A
Accession NZ_CP100521
Organism Klebsiella pneumoniae strain LH13-d

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NLZ10_RS25470 Protein ID WP_000323025.1
Coordinates 47934..48221 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NLZ10_RS25465 Protein ID WP_000534858.1
Coordinates 47695..47934 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ10_RS25435 (NLZ10_25435) 43456..43695 - 240 Protein_57 Atu4866 domain-containing protein -
NLZ10_RS25440 (NLZ10_25440) 43817..44038 - 222 WP_112029034.1 DUF1471 domain-containing protein -
NLZ10_RS25445 (NLZ10_25445) 44276..44998 - 723 WP_021314440.1 SDR family oxidoreductase -
NLZ10_RS25450 (NLZ10_25450) 45097..45996 + 900 WP_112029035.1 LysR family transcriptional regulator -
NLZ10_RS25455 (NLZ10_25455) 46101..47339 - 1239 WP_145525001.1 IS110 family transposase -
NLZ10_RS25460 (NLZ10_25460) 47572..47670 - 99 Protein_62 hypothetical protein -
NLZ10_RS25465 (NLZ10_25465) 47695..47934 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NLZ10_RS25470 (NLZ10_25470) 47934..48221 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NLZ10_RS25475 (NLZ10_25475) 48288..49322 - 1035 Protein_65 IS481 family transposase -
NLZ10_RS25480 (NLZ10_25480) 49394..49552 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
NLZ10_RS25485 (NLZ10_25485) 50157..51131 + 975 WP_049165637.1 hypothetical protein -
NLZ10_RS25490 (NLZ10_25490) 51329..51706 - 378 WP_049165636.1 hypothetical protein -
NLZ10_RS25495 (NLZ10_25495) 52023..52235 + 213 WP_046654973.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..224507 224507


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T250751 WP_000323025.1 NZ_CP100521:47934-48221 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT250751 WP_000534858.1 NZ_CP100521:47695-47934 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References