Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4640186..4640702 Replicon chromosome
Accession NZ_CP100520
Organism Klebsiella pneumoniae strain LH13-d

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NLZ10_RS22485 Protein ID WP_040237797.1
Coordinates 4640186..4640470 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NLZ10_RS22490 Protein ID WP_002886901.1
Coordinates 4640460..4640702 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ10_RS22460 (4635589) 4635589..4635852 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
NLZ10_RS22465 (4635982) 4635982..4636155 + 174 WP_032412860.1 hypothetical protein -
NLZ10_RS22470 (4636158) 4636158..4636901 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NLZ10_RS22475 (4637258) 4637258..4639396 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
NLZ10_RS22480 (4639718) 4639718..4640182 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NLZ10_RS22485 (4640186) 4640186..4640470 - 285 WP_040237797.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLZ10_RS22490 (4640460) 4640460..4640702 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NLZ10_RS22495 (4640780) 4640780..4642690 - 1911 WP_117054542.1 PRD domain-containing protein -
NLZ10_RS22500 (4642713) 4642713..4643867 - 1155 WP_040237796.1 lactonase family protein -
NLZ10_RS22505 (4643934) 4643934..4644674 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11067.91 Da        Isoelectric Point: 10.4962

>T250747 WP_040237797.1 NZ_CP100520:c4640470-4640186 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT250747 WP_002886901.1 NZ_CP100520:c4640702-4640460 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References