Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2610004..2611592 Replicon chromosome
Accession NZ_CP100520
Organism Klebsiella pneumoniae strain LH13-d

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NLZ10_RS12870 Protein ID WP_004199851.1
Coordinates 2610004..2611326 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NLZ10_RS12875 Protein ID WP_002904790.1
Coordinates 2611326..2611592 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ10_RS12855 (2605060) 2605060..2607561 + 2502 WP_100292022.1 fimbria/pilus outer membrane usher protein -
NLZ10_RS12860 (2607549) 2607549..2608553 + 1005 WP_100292021.1 fimbrial protein -
NLZ10_RS12865 (2608695) 2608695..2609987 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NLZ10_RS12870 (2610004) 2610004..2611326 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NLZ10_RS12875 (2611326) 2611326..2611592 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NLZ10_RS12880 (2611979) 2611979..2612305 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NLZ10_RS12885 (2612302) 2612302..2612802 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NLZ10_RS12890 (2612780) 2612780..2614159 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NLZ10_RS12895 (2614505) 2614505..2615659 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NLZ10_RS12900 (2615640) 2615640..2616563 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T250744 WP_004199851.1 NZ_CP100520:c2611326-2610004 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT250744 WP_002904790.1 NZ_CP100520:c2611592-2611326 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References