Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812064..812721 Replicon chromosome
Accession NZ_CP100520
Organism Klebsiella pneumoniae strain LH13-d

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NLZ10_RS04100 Protein ID WP_002916310.1
Coordinates 812311..812721 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NLZ10_RS04095 Protein ID WP_002916312.1
Coordinates 812064..812330 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ10_RS04070 (807220) 807220..808653 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
NLZ10_RS04075 (808772) 808772..809500 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NLZ10_RS04080 (809550) 809550..809861 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NLZ10_RS04085 (810025) 810025..810684 + 660 WP_002916317.1 hemolysin III family protein -
NLZ10_RS04090 (810835) 810835..811818 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
NLZ10_RS04095 (812064) 812064..812330 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NLZ10_RS04100 (812311) 812311..812721 + 411 WP_002916310.1 protein YgfX Toxin
NLZ10_RS04105 (812728) 812728..813249 - 522 WP_002916308.1 flavodoxin FldB -
NLZ10_RS04110 (813350) 813350..814246 + 897 WP_004185550.1 site-specific tyrosine recombinase XerD -
NLZ10_RS04115 (814269) 814269..814982 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NLZ10_RS04120 (814988) 814988..816721 + 1734 WP_004185546.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250739 WP_002916310.1 NZ_CP100520:812311-812721 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250739 WP_002916312.1 NZ_CP100520:812064-812330 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References