Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4926923..4928604 Replicon chromosome
Accession NZ_CP100515
Organism Klebsiella pneumoniae strain LH35-d

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag NLZ11_RS24190 Protein ID WP_254542539.1
Coordinates 4926923..4927840 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag NLZ11_RS24195 Protein ID WP_004177809.1
Coordinates 4927846..4928604 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ11_RS24170 (NLZ11_24170) 4922229..4923749 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NLZ11_RS24175 (NLZ11_24175) 4923746..4924744 + 999 WP_004872882.1 ribose ABC transporter permease -
NLZ11_RS24180 (NLZ11_24180) 4924775..4925716 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NLZ11_RS24185 (NLZ11_24185) 4925791..4926798 + 1008 WP_004177805.1 carbohydrate kinase family protein -
NLZ11_RS24190 (NLZ11_24190) 4926923..4927840 - 918 WP_254542539.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NLZ11_RS24195 (NLZ11_24195) 4927846..4928604 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NLZ11_RS24200 (NLZ11_24200) 4928690..4929418 - 729 WP_002885152.1 response regulator transcription factor -
NLZ11_RS24205 (NLZ11_24205) 4929691..4931838 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34756.26 Da        Isoelectric Point: 5.7845

>T250735 WP_254542539.1 NZ_CP100515:c4927840-4926923 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYARLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT250735 WP_004177809.1 NZ_CP100515:c4928604-4927846 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References