Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4493820..4494477 Replicon chromosome
Accession NZ_CP100515
Organism Klebsiella pneumoniae strain LH35-d

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NLZ11_RS21955 Protein ID WP_002916310.1
Coordinates 4493820..4494230 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NLZ11_RS21960 Protein ID WP_002916312.1
Coordinates 4494211..4494477 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ11_RS21935 (NLZ11_21935) 4489820..4491553 - 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -
NLZ11_RS21940 (NLZ11_21940) 4491559..4492272 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NLZ11_RS21945 (NLZ11_21945) 4492295..4493191 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NLZ11_RS21950 (NLZ11_21950) 4493292..4493813 + 522 WP_004144730.1 flavodoxin FldB -
NLZ11_RS21955 (NLZ11_21955) 4493820..4494230 - 411 WP_002916310.1 protein YgfX Toxin
NLZ11_RS21960 (NLZ11_21960) 4494211..4494477 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NLZ11_RS21965 (NLZ11_21965) 4494723..4495706 + 984 WP_038435686.1 tRNA-modifying protein YgfZ -
NLZ11_RS21970 (NLZ11_21970) 4495857..4496516 - 660 WP_002916317.1 hemolysin III family protein -
NLZ11_RS21975 (NLZ11_21975) 4496680..4496991 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NLZ11_RS21980 (NLZ11_21980) 4497041..4497769 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NLZ11_RS21985 (NLZ11_21985) 4497888..4499321 + 1434 WP_254541220.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250733 WP_002916310.1 NZ_CP100515:c4494230-4493820 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250733 WP_002916312.1 NZ_CP100515:c4494477-4494211 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References