Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2689012..2690600 Replicon chromosome
Accession NZ_CP100515
Organism Klebsiella pneumoniae strain LH35-d

Toxin (Protein)


Gene name hipA Uniprot ID A0A2X3IYA0
Locus tag NLZ11_RS13195 Protein ID WP_032103210.1
Coordinates 2689278..2690600 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NLZ11_RS13190 Protein ID WP_002904790.1
Coordinates 2689012..2689278 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ11_RS13165 (NLZ11_13165) 2684163..2685086 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
NLZ11_RS13170 (NLZ11_13170) 2685067..2686221 - 1155 WP_080893746.1 FAD-dependent urate hydroxylase HpxO -
NLZ11_RS13175 (NLZ11_13175) 2686567..2687946 + 1380 WP_004215088.1 nucleobase:cation symporter-2 family protein -
NLZ11_RS13180 (NLZ11_13180) 2687924..2688424 + 501 WP_060589175.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NLZ11_RS13185 (NLZ11_13185) 2688421..2688747 + 327 WP_101999386.1 hydroxyisourate hydrolase -
NLZ11_RS13190 (NLZ11_13190) 2689012..2689278 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NLZ11_RS13195 (NLZ11_13195) 2689278..2690600 + 1323 WP_032103210.1 type II toxin-antitoxin system HipA family toxin Toxin
NLZ11_RS13200 (NLZ11_13200) 2690617..2691909 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NLZ11_RS13205 (NLZ11_13205) 2692051..2693055 - 1005 WP_101999385.1 fimbrial protein -
NLZ11_RS13210 (NLZ11_13210) 2693043..2695544 - 2502 WP_101999384.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49097.38 Da        Isoelectric Point: 7.5357

>T250728 WP_032103210.1 NZ_CP100515:2689278-2690600 [Klebsiella pneumoniae]
MATLTTWMNNVRVGSLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT250728 WP_002904790.1 NZ_CP100515:2689012-2689278 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X3IYA0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References