Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 641742..642552 Replicon chromosome
Accession NZ_CP100515
Organism Klebsiella pneumoniae strain LH35-d

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NLZ11_RS03055 Protein ID WP_002887280.1
Coordinates 642019..642552 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NLZ11_RS03050 Protein ID WP_002887278.1
Coordinates 641742..642008 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ11_RS03030 (NLZ11_03030) 637614..637958 - 345 WP_254541403.1 cation efflux system protein CusF -
NLZ11_RS03035 (NLZ11_03035) 637976..639361 - 1386 WP_016530864.1 efflux transporter outer membrane subunit -
NLZ11_RS03040 (NLZ11_03040) 639533..640216 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
NLZ11_RS03045 (NLZ11_03045) 640206..641639 + 1434 WP_159308205.1 Cu(+)/Ag(+) sensor histidine kinase -
NLZ11_RS03050 (NLZ11_03050) 641742..642008 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NLZ11_RS03055 (NLZ11_03055) 642019..642552 + 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NLZ11_RS03060 (NLZ11_03060) 642600..643721 - 1122 WP_159308204.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T250726 WP_002887280.1 NZ_CP100515:642019-642552 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT250726 WP_002887278.1 NZ_CP100515:641742-642008 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References