Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 611857..612560 Replicon chromosome
Accession NZ_CP100515
Organism Klebsiella pneumoniae strain LH35-d

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag NLZ11_RS02920 Protein ID WP_126800543.1
Coordinates 612219..612560 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag NLZ11_RS02915 Protein ID WP_254541277.1
Coordinates 611857..612198 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ11_RS02880 (NLZ11_02880) 607010..607885 + 876 WP_254541274.1 GTPase family protein -
NLZ11_RS02885 (NLZ11_02885) 608128..608862 + 735 WP_254541275.1 WYL domain-containing protein -
NLZ11_RS02890 (NLZ11_02890) 608879..609331 + 453 WP_254541276.1 hypothetical protein -
NLZ11_RS02895 (NLZ11_02895) 609403..609876 + 474 WP_060175535.1 hypothetical protein -
NLZ11_RS02900 (NLZ11_02900) 609996..610817 + 822 WP_126800547.1 DUF932 domain-containing protein -
NLZ11_RS02905 (NLZ11_02905) 610848..611291 + 444 WP_126800546.1 antirestriction protein -
NLZ11_RS02910 (NLZ11_02910) 611304..611846 + 543 WP_126800545.1 DNA repair protein RadC -
NLZ11_RS02915 (NLZ11_02915) 611857..612198 + 342 WP_254541277.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NLZ11_RS02920 (NLZ11_02920) 612219..612560 + 342 WP_126800543.1 TA system toxin CbtA family protein Toxin
NLZ11_RS02925 (NLZ11_02925) 612753..614786 - 2034 WP_126800542.1 hypothetical protein -
NLZ11_RS02930 (NLZ11_02930) 615381..616249 - 869 Protein_577 HNH endonuclease -
NLZ11_RS02935 (NLZ11_02935) 616429..617067 + 639 WP_064152722.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 581033..615539 34506


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13023.09 Da        Isoelectric Point: 10.6066

>T250725 WP_126800543.1 NZ_CP100515:612219-612560 [Klebsiella pneumoniae]
MKTLPATTQRAAKLYLSPVAVWQMLLARLLEQHHGLILNDTPFSDEAVIQEHINAGINLADAVNFLMEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12832.50 Da        Isoelectric Point: 6.6248

>AT250725 WP_254541277.1 NZ_CP100515:611857-612198 [Klebsiella pneumoniae]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQEGNRLHYMADRASITGKFSNAEYLKLVEIFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References