Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 199722..200461 Replicon chromosome
Accession NZ_CP100515
Organism Klebsiella pneumoniae strain LH35-d

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NLZ11_RS00980 Protein ID WP_254541253.1
Coordinates 199976..200461 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag NLZ11_RS00975 Protein ID WP_003026799.1
Coordinates 199722..199988 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ11_RS00960 (NLZ11_00960) 195227..197296 + 2070 WP_065889575.1 glycine--tRNA ligase subunit beta -
NLZ11_RS00965 (NLZ11_00965) 197592..198961 + 1370 WP_087791351.1 IS3 family transposase -
NLZ11_RS00970 (NLZ11_00970) 199161..199589 + 429 WP_004901287.1 GFA family protein -
NLZ11_RS00975 (NLZ11_00975) 199722..199988 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
NLZ11_RS00980 (NLZ11_00980) 199976..200461 + 486 WP_254541253.1 GNAT family N-acetyltransferase Toxin
NLZ11_RS00985 (NLZ11_00985) 200805..200957 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
NLZ11_RS00990 (NLZ11_00990) 201259..202878 + 1620 WP_032432333.1 ATP-binding cassette domain-containing protein -
NLZ11_RS00995 (NLZ11_00995) 202977..203189 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NLZ11_RS01000 (NLZ11_01000) 203442..203732 - 291 WP_002921931.1 HTH-type transcriptional regulator -
NLZ11_RS01005 (NLZ11_01005) 203978..205333 - 1356 WP_159307981.1 aromatic acid/H+ symport family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 198236..198961 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17682.47 Da        Isoelectric Point: 10.1380

>T250721 WP_254541253.1 NZ_CP100515:199976-200461 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRDLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
LDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT250721 WP_003026799.1 NZ_CP100515:199722-199988 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References