Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4493184..4493841 Replicon chromosome
Accession NZ_CP100511
Organism Klebsiella pneumoniae strain LH50-a

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NLZ12_RS21935 Protein ID WP_002916310.1
Coordinates 4493184..4493594 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NLZ12_RS21940 Protein ID WP_002916312.1
Coordinates 4493575..4493841 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ12_RS21915 (NLZ12_21915) 4489184..4490917 - 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -
NLZ12_RS21920 (NLZ12_21920) 4490923..4491636 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NLZ12_RS21925 (NLZ12_21925) 4491659..4492555 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NLZ12_RS21930 (NLZ12_21930) 4492656..4493177 + 522 WP_004144730.1 flavodoxin FldB -
NLZ12_RS21935 (NLZ12_21935) 4493184..4493594 - 411 WP_002916310.1 protein YgfX Toxin
NLZ12_RS21940 (NLZ12_21940) 4493575..4493841 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NLZ12_RS21945 (NLZ12_21945) 4494087..4495070 + 984 WP_038435686.1 tRNA-modifying protein YgfZ -
NLZ12_RS21950 (NLZ12_21950) 4495221..4495880 - 660 WP_002916317.1 hemolysin III family protein -
NLZ12_RS21955 (NLZ12_21955) 4496044..4496355 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NLZ12_RS21960 (NLZ12_21960) 4496405..4497133 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NLZ12_RS21965 (NLZ12_21965) 4497252..4498685 + 1434 WP_254541220.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T250717 WP_002916310.1 NZ_CP100511:c4493594-4493184 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT250717 WP_002916312.1 NZ_CP100511:c4493841-4493575 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References